PELI1 explained

Protein pellino homolog 1 is a protein that in humans is encoded by the PELI1 gene.^{[1] [2] [3]}

Further reading

• Rich T . Pellino-related sequences from Caenorhabditis elegans and Homo sapiens . Immunogenetics . 52 . 1–2 . 145–149 . 2001 . 11132151 . 10.1007/s002510000249 . vanc. Allen RL . Lucas AM . 3 . Stewart . Andrew . Trowsdale . John . 13467302 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Jiang Z . Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex . J. Biol. Chem. . 278 . 13 . 10952–10956 . 2003 . 12496252 . 10.1074/jbc.M212112200 . vanc. Johnson HJ . Nie H . 3 . Qin . J . Bird . TA . Li . X . free.
• Jensen LE, Whitehead AS . Pellino2 activates the mitogen activated protein kinase pathway . FEBS Lett. . 545 . 2–3 . 199–202 . 2003 . 12804775 . 10.1016/S0014-5793(03)00533-7 . 46719284 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Butler MP, Hanly JA, Moynagh PN . Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner . J. Biol. Chem. . 280 . 30 . 27759–27768 . 2005 . 15917247 . 10.1074/jbc.M500756200 . 30374239 . free .
• Butler MP, Hanly JA, Moynagh PN . Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases . J. Biol. Chem. . 282 . 41 . 29729–29737 . 2007 . 17675297 . 10.1074/jbc.M704558200 . free .

Notes and References

1. Resch K, Jockusch H, Schmitt-John T . Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping . Cytogenet Cell Genet . 92 . 1–2 . 172–174 . Apr 2001 . 11306823 . 10.1159/000056895 . 83911010 .
2. Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH . Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1 . Nat Immunol . 7 . 10 . 1057–1065 . Sep 2006 . 16951688 . 10.1038/ni1383 . 9646386 .
3. Web site: Entrez Gene: PELI1 pellino homolog 1 (Drosophila).