PEG3 explained

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.^{[1] [2]} PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.^[3] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.^[4]

Interactions

PEG3 has been shown to interact with SIAH2^[5] and SIAH1.^[5] kjh-5oil2-*mjhac-*n.,myr0.

Further reading

• Relaix F, Wei XJ, Wu X, Sassoon DA . Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. . Nat. Genet. . 18 . 3 . 287–91 . 1998 . 9500555 . 10.1038/ng0398-287 . 1235332 .
• Relaix F, Wei X, Li W, etal . Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 5 . 2105–10 . 2000 . 10681424 . 10.1073/pnas.040378897 . 15761 . 2000PNAS...97.2105R . free .
• Kim J, Bergmann A, Stubbs L . Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). . Genomics . 64 . 1 . 114–8 . 2000 . 10708526 . 10.1006/geno.1999.6112 .
• Kohda T, Asai A, Kuroiwa Y, etal . Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. . Genes Cells . 6 . 3 . 237–47 . 2001 . 11260267 . 10.1046/j.1365-2443.2001.00412.x . 43806250 . free .
• Hiby SE, Lough M, Keverne EB, etal . Paternal monoallelic expression of PEG3 in the human placenta. . Hum. Mol. Genet. . 10 . 10 . 1093–100 . 2001 . 11331620 . 10.1093/hmg/10.10.1093 .
• Yarden RI, Brody LC . Identification of proteins that interact with BRCA1 by Far-Western library screening. . J. Cell. Biochem. . 83 . 4 . 521–31 . 2002 . 11746496 . 10.1002/jcb.1257 . 29703139 .
• Johnson MD, Wu X, Aithmitti N, Morrison RS . Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. . J. Biol. Chem. . 277 . 25 . 23000–7 . 2002 . 11943780 . 10.1074/jbc.M201907200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Mirey G, Chartrain I, Froment C, etal . CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. . Cell Cycle . 4 . 6 . 806–11 . 2006 . 15908796 . 10.4161/cc.4.6.1716. free .
• Dowdy SC, Gostout BS, Shridhar V, etal . Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. . Gynecol. Oncol. . 99 . 1 . 126–34 . 2005 . 16023706 . 10.1016/j.ygyno.2005.05.036 .
• Chartrain I, Couturier A, Tassan JP . Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. . Biol. Cell . 98 . 4 . 253–63 . 2006 . 16159311 . 10.1042/BC20050041 . 45211094 . free .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Kim J, Ashworth L, Branscomb E, Stubbs L . The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4 . Genome Res . 7 . 5 . 532–40 . August 1997 . 9149948 . 310658 . 10.1101/gr.7.5.532.
2. Web site: Entrez Gene: PEG3 paternally expressed 3.
3. 8 . 12 . e83359. Michelle M. Thiaville . Jennifer M. Huang . Hana Kim . Muhammad B. Ekram . Arundhati Bakshi . Tae-Young Roh . Joomyeong Kim . December 31, 2013. Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families. PLOS ONE. 10.1371/journal.pone.0083359. 24391757 . 3877027 . 2013PLoSO...883359K . free .
4. Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J . DNA-binding motif and target genes of the imprinted transcription factor PEG3 . Gene . 512 . 2 . 314–320 . January 2013 . 23078764 . 3513644 . 10.1016/j.gene.2012.10.005.
5. Relaix . F . Wei X j . Li W . Pan J . Lin Y . Bowtell D D . Sassoon D A . Wu X . February 2000 . Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis . . 97 . 5 . 2105–10 . UNITED STATES. 0027-8424. 10681424 . 10.1073/pnas.040378897 . 2000PNAS...97.2105R . 15761 . free .