Peflin Explained

Peflin is a protein that in humans is encoded by the PEF1 gene.^{[1] [2] [3]}

PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM]

Interactions

PEF1 has been shown to interact with PDCD6.^[4]

Further reading

• Kitaura Y, Matsumoto S, Satoh H, etal . Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. . J. Biol. Chem. . 276 . 17 . 14053–8 . 2001 . 11278427 . 10.1074/jbc.M008649200 . free .
• Satoh H, Nakano Y, Shibata H, Maki M . The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner. . Biochim. Biophys. Acta . 1600 . 1–2 . 61–7 . 2002 . 12445460 . 10.1016/S1570-9639(02)00445-4.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hansen C, Tarabykina S, la Cour JM, etal . The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. . FEBS Lett. . 545 . 2–3 . 151–4 . 2003 . 12804766 . 10.1016/S0014-5793(03)00518-0 . 42572647 .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Jordanova A, Irobi J, Thomas FP, etal . Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. . Nat. Genet. . 38 . 2 . 197–202 . 2006 . 16429158 . 10.1038/ng1727 . 16668375 .

Notes and References

1. Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M . Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region . Biochem Biophys Res Commun . 263 . 1 . 68–75 . Oct 1999 . 10486255 . 10.1006/bbrc.1999.1189 .
2. Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M . Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions . Arch Biochem Biophys . 399 . 1 . 12–8 . Mar 2002 . 11883899 . 10.1006/abbi.2001.2736 .
3. Web site: Entrez Gene: PEF1 penta-EF-hand domain containing 1.
4. Kitaura . Y . Matsumoto S . Satoh H . Hitomi K . Maki M . Apr 2001 . Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner . J. Biol. Chem. . 276 . 17 . 14053–8 . 0021-9258. 11278427 . 10.1074/jbc.M008649200 . free .