PECI (gene) explained

Peroxisomal 3,2-trans-enoyl-CoA isomerase is an enzyme that in humans is encoded by the PECI gene.^{[1] [2]}

PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Suk K, Kim YH, Hwang DY, etal . Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor . Biochim. Biophys. Acta . 1454 . 1 . 126–31 . 1999 . 10354522 . 10.1016/s0925-4439(99)00033-2.
• Scanlan MJ, Gordan JD, Williamson B, etal . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . Int. J. Cancer . 83 . 4 . 456–64 . 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . 21839750 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Suzuki Y, Tsunoda T, Sese J, etal . Identification and characterization of the potential promoter regions of 1031 kinds of human genes . Genome Res. . 11 . 5 . 677–84 . 2001 . 11337467 . 10.1101/gr.gr-1640r . 311086 .
• Janssen U, Stoffel W . Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse . J. Biol. Chem. . 277 . 22 . 19579–84 . 2002 . 11916962 . 10.1074/jbc.M110993200 . free .
• Wang Y, Han KJ, Pang XW, etal . Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies . J. Immunol. . 169 . 2 . 1102–9 . 2002 . 12097419 . 10.4049/jimmunol.169.2.1102. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Feng X, Chuhjo T, Sugimori C, etal . Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells . Blood . 104 . 8 . 2425–31 . 2004 . 15217832 . 10.1182/blood-2004-05-1839 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Geisbrecht BV, Zhang D, Schulz H, Gould SJ . Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes . J Biol Chem . 274 . 31 . 21797–803 . Aug 1999 . 10419495 . 10.1074/jbc.274.31.21797 . free .
2. Web site: Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase.