PD 144418 explained

PD 144418 or 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of K_i = 0.08 ± 0.01 nM, and 17 212 times selectivity over the sigma-2 receptor.^[1]

Notes and References

1. Akunne HC, Whetzel SZ, Wiley JN, Corbin AE, Ninteman FW, Tecle H, Pei Y, Pugsley TA, Heffner TG . The pharmacology of the novel and selective sigma ligand, PD 144418 . Neuropharmacology . 36 . 1 . 51–62 . January 1997 . 9144641 . 10.1016/S0028-3908(96)00161-X . 1356055 .