PDSS2 explained

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.^[1]

Function

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.^[1]

Clinical significance

It may be associated with Coenzyme Q10 deficiency.

See also

• PDSS1

Further reading

• Talmud PJ, Drenos F, Shah S, etal . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. . Am. J. Hum. Genet. . 85 . 5 . 628–42 . 2009 . 19913121 . 10.1016/j.ajhg.2009.10.014 . 2775832.
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Diomedi-Camassei F, Di Giandomenico S, Santorelli FM, etal . COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. . J. Am. Soc. Nephrol. . 18 . 10 . 2773–80 . 2007 . 17855635 . 10.1681/ASN.2006080833 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8.
• Cui TZ, Kaino T, Kawamukai M . A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex. . FEBS Lett. . 584 . 4 . 652–6 . 2010 . 20051244 . 10.1016/j.febslet.2009.12.029 . 41737114 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Saiki R, Nagata A, Kainou T, etal . Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. . FEBS J. . 272 . 21 . 5606–22 . 2005 . 16262699 . 10.1111/j.1742-4658.2005.04956.x . 13735213 . free .
• Machuca E, Benoit G, Nevo F, etal . Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome. . J. Am. Soc. Nephrol. . 21 . 7 . 1209–17 . 2010 . 20507940 . 10.1681/ASN.2009121309 . 3152225.
• Chen P, Zhao SH, Chu YL, etal . Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line. . Anticancer Drugs . 20 . 2 . 141–8 . 2009 . 19209031 . 10.1097/CAD.0b013e32832016a9 . 19932575 .
• Hendrickson SL, Lautenberger JA, Chinn LW, etal . Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. . PLOS ONE . 5 . 9 . e12862 . 2010 . 20877624 . 10.1371/journal.pone.0012862 . 2943476. 2010PLoSO...512862H . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3.
• Vieira AR, McHenry TG, Daack-Hirsch S, etal . Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. . Genet. Med. . 10 . 9 . 668–74 . 2008 . 18978678 . 10.1097/GIM.0b013e3181833793 . 2734954.
• Bailey SD, Xie C, Do R, etal . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. . Diabetes Care . 33 . 10 . 2250–3 . 2010 . 20628086 . 10.2337/dc10-0452 . 2945168.

Notes and References

1. Web site: Entrez Gene: prenyl (decaprenyl) diphosphate synthase.