PDLIM7 explained

PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene.^{[1] [2]}

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.

Interactions

PDLIM7 has been shown to interact with TPM2.^[3]

Further reading

• Bach I . The LIM domain: regulation by association . Mechanisms of Development . 91 . 1–2 . 5–17 . March 2000 . 10704826 . 10.1016/S0925-4773(99)00314-7 . 16093470 .
• Wu RY, Gill GN . LIM domain recognition of a tyrosine-containing tight turn . The Journal of Biological Chemistry . 269 . 40 . 25085–90 . October 1994 . 10.1016/S0021-9258(17)31502-8 . 7929196 . free .
• Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill GN, Kikkawa U . 6 . Protein-protein interaction of zinc finger LIM domains with protein kinase C . The Journal of Biological Chemistry . 271 . 49 . 31029–32 . December 1996 . 8940095 . 10.1074/jbc.271.49.31029 . free .
• Durick K, Gill GN, Taylor SS . Shc and Enigma are both required for mitogenic signaling by Ret/ptc2 . Molecular and Cellular Biology . 18 . 4 . 2298–308 . April 1998 . 9528800 . 121481 . 10.1128/mcb.18.4.2298 .
• Guy PM, Kenny DA, Gill GN . The PDZ domain of the LIM protein enigma binds to beta-tropomyosin . Molecular Biology of the Cell . 10 . 6 . 1973–84 . June 1999 . 10359609 . 25398 . 10.1091/mbc.10.6.1973 .
• Borrello MG, Mercalli E, Perego C, Degl'Innocenti D, Ghizzoni S, Arighi E, Eroini B, Rizzetti MG, Pierotti MA . 6 . Differential interaction of Enigma protein with the two RET isoforms . Biochemical and Biophysical Research Communications . 296 . 3 . 515–22 . August 2002 . 12176011 . 10.1016/S0006-291X(02)00886-0 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . January 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Sangadala S, Boden SD, Viggeswarapu M, Liu Y, Titus L . LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads . The Journal of Biological Chemistry . 281 . 25 . 17212–9 . June 2006 . 16611643 . 10.1074/jbc.M511013200 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . 6 . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Barrès R, Grémeaux T, Gual P, Gonzalez T, Gugenheim J, Tran A, Le Marchand-Brustel Y, Tanti JF . 6 . Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation . Molecular Endocrinology . 20 . 11 . 2864–75 . November 2006 . 16803868 . 1892539 . 10.1210/me.2005-0455 .

Notes and References

1. Liu Y, Hair GA, Boden SD, Viggeswarapu M, Titus L . Overexpressed LIM mineralization proteins do not require LIM domains to induce bone . Journal of Bone and Mineral Research . 17 . 3 . 406–14 . March 2002 . 11874232 . 10.1359/jbmr.2002.17.3.406 . 26089809 . free .
2. Web site: Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma).
3. Guy PM, Kenny DA, Gill GN . The PDZ domain of the LIM protein enigma binds to beta-tropomyosin . Molecular Biology of the Cell . 10 . 6 . 1973–84 . June 1999 . 10359609 . 25398 . 10.1091/mbc.10.6.1973 .