PDLIM1 explained

PDZ and LIM domain protein 1 is a protein that in humans is encoded by the PDLIM1 gene.^{[1] [2]}

Interactions

PDLIM1 has been shown to interact with:

• Actinin alpha 4,^{[3] [4]}
• Actinin, alpha 1,^{[4] [5]}
• Estrogen receptor alpha,^[6] and
• RNF12.^[6]

Further reading

• Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B . Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL. . Gene . 165 . 2 . 267–71 . 1996 . 8522188 . 10.1016/0378-1119(95)00542-E .
• Kotaka M, Ngai SM, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM . Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1). . J. Cell. Biochem. . 72 . 2 . 279–85 . 1999 . 10022510 . 10.1002/(SICI)1097-4644(19990201)72:2<279::AID-JCB12>3.0.CO;2-7 . 23811125 .
• Vallenius T, Luukko K, Mäkelä TP . CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4. . J. Biol. Chem. . 275 . 15 . 11100–5 . 2000 . 10753915 . 10.1074/jbc.275.15.11100 . free .
• Bauer K, Kratzer M, Otte M, de Quintana KL, Hagmann J, Arnold GJ, Eckerskorn C, Lottspeich F, Siess W . Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells. . Blood . 96 . 13 . 4236–45 . 2001 . 11110697 . 10.1182/blood.V96.13.4236.
• Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I . Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. . Nature . 416 . 6876 . 99–103 . 2002 . 11882901 . 10.1038/416099a . 2002Natur.416...99O . 4426785 .
• Vallenius T, Mäkelä TP . Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. . J. Cell Sci. . 115 . Pt 10 . 2067–73 . 2003 . 10.1242/jcs.115.10.2067 . 11973348 .
• Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P, Nguyen HD, Kemler R, Glass CK, Wynshaw-Boris A, Rosenfeld MG . Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. . Cell . 111 . 5 . 673–85 . 2003 . 12464179 . 10.1016/S0092-8674(02)01084-X . 16108479 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Miehe U, Kadyrov M, Neumaier-Wagner P, Bartz C, Rath W, Huppertz B . Expression of the actin stress fiber-associated protein CLP36 in the human placenta. . Histochem. Cell Biol. . 126 . 4 . 465–71 . 2007 . 16609848 . 10.1007/s00418-006-0182-5 . 22394948 .

Notes and References

1. Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, ((Li Hy)), Ng EK, Schaper J, Tsui SK, ((Fung Kp)), ((Lee Cy)), Waye MM . Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2 . J Cell Biochem . 78 . 4 . 558–65 . October 2000 . 10861853 . 10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I . 84122657 .
2. Web site: Entrez Gene: PDLIM1 PDZ and LIM domain 1 (elfin).
3. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
4. Vallenius T, Luukko K, Mäkelä TP . CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4 . J. Biol. Chem. . 275 . 15 . 11100–5 . April 2000 . 10753915 . 10.1074/jbc.275.15.11100. free .
5. Bauer K, Kratzer M, Otte M, de Quintana KL, Hagmann J, Arnold GJ, Eckerskorn C, Lottspeich F, Siess W . Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells . Blood . 96 . 13 . 4236–45 . December 2000 . 11110697 . 10.1182/blood.V96.13.4236.
6. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I . Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer . Cancer Res. . 69 . 1 . 128–36 . January 2009 . 19117995 . 2713826 . 10.1158/0008-5472.CAN-08-1630 .