PDGFD explained

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.

Further reading

• Bergsten E, Uutela M, Li X, etal . PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor . Nat. Cell Biol. . 3 . 5 . 512–6 . 2001 . 11331881 . 10.1038/35074588 . 25074372 .
• LaRochelle WJ, Jeffers M, McDonald WF, etal . PDGF-D, a new protease-activated growth factor . Nat. Cell Biol. . 3 . 5 . 517–21 . 2001 . 11331882 . 10.1038/35074593 . 19633551 .
• Uutela M, Laurén J, Bergsten E, etal . Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes . Circulation . 103 . 18 . 2242–7 . 2001 . 11342471 . 10.1161/01.cir.103.18.2242. free .
• Wistow G, Bernstein SL, Ray S, etal . Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium . Mol. Vis. . 8 . 185–95 . 2002 . 12107412 .
• Changsirikulchai S, Hudkins KL, Goodpaster TA, etal . Platelet-derived growth factor-D expression in developing and mature human kidneys . Kidney Int. . 62 . 6 . 2043–54 . 2003 . 12427128 . 10.1046/j.1523-1755.2002.00662.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Taneda S, Hudkins KL, Topouzis S, etal . Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury . J. Am. Soc. Nephrol. . 14 . 10 . 2544–55 . 2004 . 14514732 . 10.1097/01.ASN.0000089828.73014.C8 . free .
• Uutela M, Wirzenius M, Paavonen K, etal . PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis . Blood . 104 . 10 . 3198–204 . 2004 . 15271796 . 10.1182/blood-2004-04-1485 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ray S, Gao C, Wyatt K, etal . Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation . J. Biol. Chem. . 280 . 9 . 8494–502 . 2005 . 15611105 . 10.1074/jbc.M413570200 . free .
• Ustach CV, Kim HR . Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells . Mol. Cell. Biol. . 25 . 14 . 6279–88 . 2005 . 15988036 . 10.1128/MCB.25.14.6279-6288.2005 . 1168822 .
• Liu MY, Eyries M, Zhang C, etal . Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1 . Blood . 107 . 6 . 2322–9 . 2006 . 16189269 . 10.1182/blood-2005-06-2377 . free .

Notes and References

1. Hamada T, Ui-Tei K, Imaki J, Miyata Y . Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein . Biochem Biophys Res Commun . 280 . 3 . 733–7 . Feb 2001 . 11162582 . 10.1006/bbrc.2000.4187 .
2. LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS . Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer . Cancer Res . 62 . 9 . 2468–73 . Apr 2002 . 11980634 .
3. Web site: Entrez Gene: PDGFD platelet derived growth factor D.