PDF (gene) explained

PDF (gene) should not be confused with Pigment dispersing factor.

Peptide deformylase, mitochondrial is an enzyme that in humans is encoded by the PDF gene.^{[1] [2] [3]}

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Lee MD, Antczak C, Li Y, etal . A new human peptide deformylase inhibitable by actinonin. . Biochem. Biophys. Res. Commun. . 312 . 2 . 309–15 . 2004 . 14637138 . 10.1016/j.bbrc.2003.10.123 .
• Serero A, Giglione C, Sardini A, etal . An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. . J. Biol. Chem. . 278 . 52 . 52953–63 . 2004 . 14532271 . 10.1074/jbc.M309770200 . free .
• Nguyen KT, Hu X, Colton C, etal . Characterization of a human peptide deformylase: implications for antibacterial drug design. . Biochemistry . 42 . 33 . 9952–8 . 2003 . 12924944 . 10.1021/bi0346446 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chagnon P, Michaud J, Mitchell G, etal . A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. . Am. J. Hum. Genet. . 71 . 6 . 1443–9 . 2003 . 12417987 . 10.1086/344580 . 378590 .

Notes and References

1. Giglione C, Serero A, Pierre M, Boisson B, Meinnel T . Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms . EMBO J . 19 . 21 . 5916–29 . Nov 2000 . 11060042 . 305796 . 10.1093/emboj/19.21.5916 .
2. Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA . Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics . J Clin Invest . 114 . 8 . 1107–16 . Oct 2004 . 15489958 . 522256 . 10.1172/JCI22269 .
3. Web site: Entrez Gene: PDF peptide deformylase (mitochondrial).