Phorbol-diester hydrolase explained

phorbol-diester hydrolase
Ec Number:	3.1.1.51
Cas Number:	81181-74-0
Go Code:	0050181

The enzyme phorbol-diester hydrolase (EC 3.1.1.51) catalyzes the reaction

phorbol 12,13-dibutanoate + H₂O

\rightleftharpoons phorbol 13-butanoate + butanoate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.

References

• Shoyab M, Warren TC, Todaro GJ . 1981 . Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver . J. Biol. Chem. . 256 . 12529 - 34 . 6946062 . 23 .