PDE8B explained

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.^{[1] [2]}

Further reading

• Dias Neto E . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . vanc. Correa RG . Verjovski-Almeida S . 3 . Briones . MR . Nagai . MA . Da Silva Jr . W . Zago . MA . Bordin . S . Costa . FF . 2000PNAS...97.3491D . free .
• Persani L . Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations . J. Clin. Endocrinol. Metab. . 86 . 8 . 3795–800 . 2001 . 11502813 . vanc. Borgato S . Lania A . 3 . Filopanti . M . Mantovani . G . Conti . M . Spada . A . 10.1210/jcem.86.8.7779 . free .
• Hayashi M . Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene . Biochem. Biophys. Res. Commun. . 297 . 5 . 1253–8 . 2002 . 12372422 . 10.1016/S0006-291X(02)02371-9 . vanc. Shimada Y . Nishimura Y . 3 . Hama . Takaaki . Tanaka . Toshio .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gamanuma M . Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans . Cell. Signal. . 15 . 6 . 565–74 . 2003 . 12681444 . 10.1016/S0898-6568(02)00146-8 . vanc. Yuasa K . Sasaki T . 3 . Sakurai . Naoki . Kotera . Jun . Omori . Kenji .
• Pérez-Torres S . Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization . Exp. Neurol. . 182 . 2 . 322–34 . 2003 . 12895443 . 10.1016/S0014-4886(03)00042-6 . vanc. Cortés R . Tolnay M . 3 . Probst . A . Palacios . J.M . Mengod . G . 10261/112629 . 12150443 . free.
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Brill LM . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d . vanc. Salomon AR . Ficarro SB . 3 . Mukherji . Mridul . Stettler-Gill . Michelle . Peters . Eric C. .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T . Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase . Biochem Biophys Res Commun . 250 . 3 . 751–6 . Nov 1998 . 9784418 . 10.1006/bbrc.1998.9379 .
2. Web site: Entrez Gene: PDE8B phosphodiesterase 8B.