PDE6G explained

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.^{[1] [2] [3]}

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase^[4] and Src.^[4]

Further reading

• Cotran PR, Bruns GA, Berson EL, Dryja TP . Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase . Experimental Eye Research . 53 . 5 . 557–64 . November 1991 . 1683837 . 10.1016/0014-4835(91)90213-X .
• Piriev NI, Purishko VA, Khramtsov NV, Lipkin VM . [The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase] . Doklady Akademii Nauk SSSR . 315 . 1 . 229–31 . 1991 . 1965799 . The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase .
• Tuteja N, Danciger M, Klisak I, Tuteja R, Inana G, Mohandas T, Sparkes RS, Farber DB . Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina . Gene . 88 . 2 . 227–32 . April 1990 . 2161380 . 10.1016/0378-1119(90)90035-P .
• Piriev NI, Khramtsov NV, Lipkin VM . Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells . Gene . 151 . 1–2 . 297–301 . December 1994 . 7828894 . 10.1016/0378-1119(94)90674-2 .
• Hahn LB, Berson EL, Dryja TP . Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa . Investigative Ophthalmology & Visual Science . 35 . 3 . 1077–82 . March 1994 . 8125719 .
• Dollfus H, Mattei MG, Rozet JM, Delrieu O, Munnich A, Kaplan J . Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25) . Genomics . 17 . 2 . 526–8 . August 1993 . 8406511 . 10.1006/geno.1993.1364 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Wan KF, Sambi BS, Frame M, Tate R, Pyne NJ . The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells . The Journal of Biological Chemistry . 276 . 41 . 37802–8 . October 2001 . 11502744 . 10.1074/jbc.M105087200 . free .
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts . Molecular Vision . 8 . 196–204 . June 2002 . 12107411 .
• Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ . The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor . The Journal of Biological Chemistry . 278 . 20 . 18658–63 . May 2003 . 12624098 . 10.1074/jbc.M212103200 . 25824189 . free .
• Morin F, Vannier B, Houdart F, Regnacq M, Berges T, Voisin P . A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins . Molecular Vision . 9 . 449–59 . September 2003 . 14502124 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . October 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415-8 . January 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

Notes and References

1. Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL . Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene . Genomics . 6 . 2 . 272–83 . February 1990 . 2155175 . 10.1016/0888-7543(90)90567-E .
2. Web site: Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma.
3. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L . Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases . Science Advances . 5 . 2 . eaav4322 . February 2019 . 30820458 . 6392808 . 10.1126/sciadv.aav4322 . 2019SciA....5.4322G .
4. Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ . The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor . The Journal of Biological Chemistry . 278 . 20 . 18658–63 . May 2003 . 12624098 . 10.1074/jbc.M212103200 . 25824189 . free .