PDE4C explained

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.^[1]

Tissue localisation

PDE4C is predominantly found in peripheral tissues.^[2]

Further reading

• Engels P, Sullivan M, Müller T, Lübbert H . Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). . FEBS Lett. . 358 . 3 . 305–10 . 1995 . 7843419 . 10.1016/0014-5793(94)01460-I . 24276391 . free .
• Milatovich A, Bolger G, Michaeli T, Francke U . Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. . Somat. Cell Mol. Genet. . 20 . 2 . 75–86 . 1994 . 8009369 . 10.1007/BF02290677 . 19182571 .
• Bolger G, Michaeli T, Martins T, etal . A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs . Mol. Cell. Biol. . 13 . 10 . 6558–71 . 1993 . 8413254 . 10.1128/mcb.13.10.6558. 364715 .
• Obernolte R, Ratzliff J, Baecker PA, etal . Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis . Biochim. Biophys. Acta . 1353 . 3 . 287–97 . 1997 . 9349724 . 10.1016/s0167-4781(97)00080-8.
• Owens RJ, Lumb S, Rees-Milton K, etal . Molecular cloning and expression of a human phosphodiesterase 4C . Cell. Signal. . 9 . 8 . 575–85 . 1998 . 9429761 . 10.1016/S0898-6568(97)00072-7 .
• Sullivan M, Olsen AS, Houslay MD . Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND . Cell. Signal. . 11 . 10 . 735–42 . 2000 . 10574328 . 10.1016/S0898-6568(99)00037-6 .
• Zauli G, Milani D, Mirandola P, etal . HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway . FASEB J. . 15 . 2 . 483–91 . 2001 . 11156964 . 10.1096/fj.00-0354com . free . 26315564 .
• Pérez-Torres S, Miró X, Palacios JM, etal . Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain . J. Chem. Neuroanat. . 20 . 3–4 . 349–74 . 2001 . 11207431 . 10.1016/S0891-0618(00)00097-1 . 10261/112708 . 25012736 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Johnson JM, Castle J, Garrett-Engele P, etal . Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays . Science . 302 . 5653 . 2141–4 . 2004 . 14684825 . 10.1126/science.1090100 . 10007258 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .

Notes and References

1. Web site: Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila).
2. Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs. Current Pharmaceutical Design. 2009. 15. 14. 1688–1698. 10.2174/138161209788168092. 19442182. Zhang, HT.