PDE2A explained

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^{[1] [2]}

Further reading

• Witzenrath M . Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia . Critical Care Medicine . 37. 9 . 584–590 . 2005 . 19114892 . 10.1097/CCM.0b013e3181959814 . Gutbier B . Schmeck B . Tenor . Herrmann . Seybold . Joachim . Kuelzer . Raimund . Grentzmann . Guido . Hatzelmann . Armin . Van Laak . Vincent. 1060183 .
• Seybold J . Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability . Blood . 105 . 9 . 3569–3576 . 2009 . 15650061 . 10.1182/blood-2004-07-2729 . Thomas D . Witzenrath M . Boral . S . Hocke . AC . Bürger . A . Hatzelmann . A . Tenor . H . Schudt . C . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Martinez SE . The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding . Proc. Natl. Acad. Sci. U.S.A. . 99 . 20 . 13260–13265 . 2002 . 12271124 . 10.1073/pnas.192374899 . 130621 . Wu AY . Glavas NA . Tang . XB . Turley . S . Hol . WG . Beavo . JA . 2002PNAS...9913260M . free .
• Manns JM, Brenna KJ, Colman RW, Sheth SB . Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases . Thromb. Haemost. . 87 . 5 . 873–9 . 2002 . 12038792 . 10.1055/s-0037-1613099. 4637804 .
• Zauli G . HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway . FASEB J. . 15 . 2 . 483–491 . 2001 . 11156964 . 10.1096/fj.00-0354com . Milani D . Mirandola P . Mazzoni . M . Secchiero . P . Miscia . S . Capitani . S . free . 26315564 .
• Sadhu K, Hensley K, Florio VA, Wolda SL . Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells . J. Histochem. Cytochem. . 47 . 7 . 895–906 . 1999 . 10375378 . 10.1177/002215549904700707 . free .

Notes and References

1. Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K . Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase . Gene . 191 . 1 . 89–95 . Aug 1997 . 9210593 . 10.1016/S0378-1119(97)00046-2 .
2. Web site: Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated.