PDE1A explained

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.^{[1] [2] [3]}

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Snyder PB, Florio VA, Ferguson K, Loughney K . Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A). . Cell. Signal. . 11 . 7 . 535–44 . 1999 . 10405764 . 10.1016/S0898-6568(99)00027-3 .
• Zauli G, Milani D, Mirandola P, etal . HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. . FASEB J. . 15 . 2 . 483–91 . 2001 . 11156964 . 10.1096/fj.00-0354com . free . 26315564 .
• Harrington JJ, Sherf B, Rundlett S, etal . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 .
• Yan C, Zhao AZ, Sonnenburg WK, Beavo JA . Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis. . Biol. Reprod. . 64 . 6 . 1746–54 . 2001 . 11369604 . 10.1095/biolreprod64.6.1746 . free .
• Fidock M, Miller M, Lanfear J . Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. . Cell. Signal. . 14 . 1 . 53–60 . 2002 . 11747989 . 10.1016/S0898-6568(01)00207-8 .
• Ritter M, Buechler C, Boettcher A, etal . Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. . Genomics . 79 . 5 . 693–702 . 2002 . 11991719 . 10.1006/geno.2002.6761 .
• Lefièvre L, de Lamirande E, Gagnon C . Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. . Biol. Reprod. . 67 . 2 . 423–30 . 2003 . 12135876 . 10.1095/biolreprod67.2.423 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Goraya TA, Masada N, Ciruela A, Cooper DM . Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A . J. Biol. Chem. . 279 . 39 . 40494–504 . 2004 . 15272012 . 10.1074/jbc.M313441200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Nagel DJ, Aizawa T, Jeon KI, etal . Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival . Circ. Res. . 98 . 6 . 777–84 . 2006 . 16514069 . 10.1161/01.RES.0000215576.27615.fd . 4114760 .

Notes and References

1. Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K . Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases . J Biol Chem . 271 . 2 . 796–806 . Feb 1996 . 8557689 . 10.1074/jbc.271.2.796 . free .
2. Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K . Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization . Biochim Biophys Acta . 1517 . 2 . 278–87 . May 2001 . 11342109 . 10.1016/s0167-4781(00)00293-1.
3. Web site: Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent.