PDCD5 explained

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein,^[1] that in humans is encoded by the PDCD5 gene.^{[2] [3]}

This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.

Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.

Further reading

• Park SY, Hong JY, Lee SY, Lee SH, Kim MJ, Kim SY, Kim KW, Shim HS, Park MS, Lee CG, Elias JA, Sohn MH, Yoon HG . Club cell-specific role of programmed cell death 5 in pulmonary fibrosis . Nature Communications . 12 . 1 . 2923 . May 2021 . 34011956 . 8134485 . 10.1038/s41467-021-23277-8 . 2021NatCo..12.2923P .
• Huang Y, Zhang J, Yang J . ATF3 drives cell senescence through TGFβ/Pdcd5 pathway in cardiac myocyte . International Journal of Cardiology . 348 . 118 . February 2022 . 34856292 . 10.1016/j.ijcard.2021.11.067 . 244788447 .
• Naz A, Zhang S, An L, Song Z, Zi Z, Wu J, Lai S, Mazhar H, Xu M, Chen Y, Zou Y, He L, Zhu H . Muscle-specific programmed cell death 5 deletion attenuates cardiac aging . International Journal of Cardiology . 345 . 98–104 . December 2021 . 34710491 . 10.1016/j.ijcard.2021.10.142 . 239981053 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Chen Y, Sun R, Han W, Zhang Y, Song Q, Di C, Ma D . Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis? . FEBS Letters . 509 . 2 . 191–196 . December 2001 . 11741587 . 10.1016/S0014-5793(01)03062-9 . 26547410 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–569 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Xu M, Cheng N, Gui L, Lai M, Wang Y, Xia D, Rui M, Zhang Y, Ma D . The 5'-upstream region of human programmed cell death 5 gene contains a highly active TATA-less promoter that is up-regulated by etoposide . Gene . 329 . 39–49 . March 2004 . 15033527 . 10.1016/j.gene.2003.12.025 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–12135 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Liu D, Yao H, Chen Y, Feng Y, Chen Y, Wang J . The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character . The Biochemical Journal . 392 . Pt 1 . 47–54 . November 2005 . 16083422 . 1317663 . 10.1042/BJ20050688 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–968 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 8235923 . 11858/00-001M-0000-0010-8592-0 .
• Ma X, Ruan G, Wang Y, Li Q, Zhu P, Qin YZ, Li JL, Liu YR, Ma D, Zhao H . Two single-nucleotide polymorphisms with linkage disequilibrium in the human programmed cell death 5 gene 5' regulatory region affect promoter activity and the susceptibility of chronic myelogenous leukemia in Chinese population . Clinical Cancer Research . 11 . 24 Pt 1 . 8592–8599 . December 2005 . 16361542 . 10.1158/1078-0432.CCR-05-0039 . 3094976 .
• Yang YH, Zhao M, Li WM, Lu YY, Chen YY, Kang B, Lu YY . Expression of programmed cell death 5 gene involves in regulation of apoptosis in gastric tumor cells . Apoptosis . 11 . 6 . 993–1001 . June 2006 . 16547588 . 10.1007/s10495-006-6714-6 . 21178139 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Wang N, Lu HS, Guan ZP, Sun TZ, Chen YY, Ruan GR, Chen ZK, Jiang J, Bai CJ . Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis . Apoptosis . 12 . 8 . 1433–1441 . August 2007 . 17468978 . 10.1007/s10495-007-0070-z . 21175365 .

Notes and References

1. Li G, Ma D, Chen Y . Cellular functions of programmed cell death 5 . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1863 . 4 . 572–580 . April 2016 . 26775586 . 10.1016/j.bbamcr.2015.12.021 . free .
2. Liu H, Wang Y, Zhang Y, Song Q, Di C, Chen G, Tang J, Ma D . TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal . Biochemical and Biophysical Research Communications . 254 . 1 . 203–210 . January 1999 . 9920759 . 10.1006/bbrc.1998.9893 .
3. Web site: Entrez Gene: PDCD5 programmed cell death 5.