PDCD2 explained

Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene.^{[1] [2]}

Function

This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Six transcripts encoding different proteins have been identified.

Interactions

PDCD2 has been shown to interact with Host cell factor C1^[3] and Parkin (ligase).^[4]

Further reading

• Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, Kim DC, Simone F, Birkenbach M, Montag A, Sadhu A, Zeleznik-Le N, McKeithan TW . The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis . Proceedings of the National Academy of Sciences of the United States of America . 99 . 5 . 2860–5 . Mar 2002 . 11854457 . 122438 . 10.1073/pnas.042702599 . 2002PNAS...99.2860B . free .
• Scarr RB, Sharp PA . PDCD2 is a negative regulator of HCF-1 (C1) . Oncogene . 21 . 34 . 5245–54 . Aug 2002 . 12149646 . 10.1038/sj.onc.1205647 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nature Cell Biology . 6 . 2 . 97–105 . Feb 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Chen Q, Qian K, Yan C . Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells . Molecular and Cellular Biochemistry . 280 . 1–2 . 185–91 . Dec 2005 . 16311922 . 10.1007/s11010-005-8910-z . 6208880 .
• Baron BW, Zeleznik-Le N, Baron MJ, Theisler C, Huo D, Krasowski MD, Thirman MJ, Baron RM, Baron JM . Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas . Proceedings of the National Academy of Sciences of the United States of America . 104 . 18 . 7449–54 . May 2007 . 17468402 . 1863460 . 10.1073/pnas.0701770104 . 2007PNAS..104.7449B . free .

Notes and References

1. Kawakami T, Furukawa Y, Sudo K, Saito H, Takami S, Takahashi E, Nakamura Y . Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death . Cytogenetics and Cell Genetics . 71 . 1 . 41–3 . Aug 1995 . 7606924 . 10.1159/000134058 .
2. Web site: Entrez Gene: PDCD2 programmed cell death 2.
3. Scarr RB, Sharp PA . PDCD2 is a negative regulator of HCF-1 (C1) . Oncogene . 21 . 34 . 5245–54 . Aug 2002 . 12149646 . 10.1038/sj.onc.1205647 . free .
4. Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N . Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease . FEBS Letters . 583 . 3 . 521–5 . Feb 2009 . 19146857 . 10.1016/j.febslet.2008.12.055 . 1721.1/96274 . 7121769 . free .