PDC-APB explained

Width:250px
Cas Number:2016046-95-8
Pubchem:89683272
Unii:LX6RQK5701
Synonyms:3-Pentadecyl-1,2-phenylene bis(4-(4-aminophenyl)butanoate; Benzenebutanoic acid, 4-amino-, 1,1'-(3-pentadecyl-1,2-phenylene) ester
Iupac Name:[2-[4-(4-aminophenyl)butanoyloxy]-3-pentadecylphenyl] 4-(4-aminophenyl)butanoate
C:41
H:58
N:2
O:4
Smiles:CCCCCCCCCCCCCCCC1=C(C(=CC=C1)OC(=O)CCCC2=CC=C(C=C2)N)OC(=O)CCCC3=CC=C(C=C3)N
Stdinchi:1S/C41H58N2O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-20-35-21-17-22-38(46-39(44)23-15-18-33-25-29-36(42)30-26-33)41(35)47-40(45)24-16-19-34-27-31-37(43)32-28-34/h17,21-22,25-32H,2-16,18-20,23-24,42-43H2,1H3
Stdinchikey:VLRZIRYGLUVGGU-UHFFFAOYSA-N

PDC-APB, or 3-pentadecyl-1,2-phenylene bis(4-(4-aminophenyl)butanoate),[1] is a drug candidate under evaluation to determine if it might protect against contact dermatitis caused by urishiol from poison ivy, poison oak, and poison sumac.[2] [3] [4]

History

The compound is one of a class of compounds developed through University of Mississippi research[5] by Mahmoud ElSohly, Waseem Gul, and Mohammad Khalid Ashfaq. Work on the compound is ongoing under Hapten Sciences,[6] who licensed the university's research in 2010.

Evaluation as a drug candidate

The compound has been evaluated in two Phase I clinical trials, and a third Phase I randomized controlled trial, with a secondary objective of evaluating the effect of treatment on urishiol sensitivity, is due to be completed in December 2022.[7]

See also

Notes and References

  1. US . 10322103 . Elsohly M, Gul M, Ashfaq MK . University of Mississippi . patent . Compositions for prevention/prophylactic treatment of poison ivy dermatitis . 18 June 2019 .
  2. News: Wallis C . A Vaccine against Poison Ivy Misery Is in the Works as Scientists Also Explore New Treatment Paths . 27 July 2022 . Scientific American . 1 September 2021 . 30 March 2022 . https://web.archive.org/web/20220330113258/https://www.scientificamerican.com/article/a-vaccine-against-poison-ivy-misery-is-in-the-works-as-scientists-also-explore-new-treatment-paths/ . live .
  3. News: O'Laughlin F . Report: Vaccine that guards against poison ivy misery in the works . 27 July 2022 . WHDH TV . 23 September 2021 . 23 September 2021 . https://web.archive.org/web/20210923232430/https://whdh.com/news/report-vaccine-that-guards-against-poison-ivy-misery-in-the-works/ . live .
  4. Kim Y, Flamm A, ElSohly MA, Kaplan DH, Hage RJ, Hamann CP, Marks JG . Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New? . Dermatitis . 30 . 3 . 183–190 . 2019 . 31045932 . 10.1097/DER.0000000000000472 . 143423493 .
  5. News: Stewart S . University Obtains New Patent for Poison Ivy, Oak Vaccine Compound in clinical development with Memphis-based company . 27 July 2022 . RedHillsMSNews.com . Winston County Journal . 18 June 2019 . en . 19 June 2019 . https://web.archive.org/web/20190619131014/https://www.redhillsmsnews.com/news/university-obtains-new-patent-poison-ivy-oak-vaccine-compound-clinical-development-memphis . live .
  6. News: Jefferson R . University of Mississippi and Hapten's Poison Ivy Vaccine Development Now in Clinical Trials . 27 July 2022 . The Science Times . 22 September 2021 . 23 September 2021 . https://web.archive.org/web/20210923145429/https://www.sciencetimes.com/articles/33586/20210922/university-mississippi-haptens-poison-ivy-vaccine-development-now-clinical-trials.htm . live .
  7. News: Doctor V . A Prophylactic for Poison Ivy? Phase I Trial Set to Begin . 27 July 2022 . BioSpace . 22 September 2021 . 2 October 2021 . https://web.archive.org/web/20211002164041/https://www.biospace.com/article/phase-i-trial-for-poison-ivy-vaccine-set-to-begin-in-november-/ . live .

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