PD-102,807 explained

PD-102,807 is a drug which acts as a selective antagonist for the muscarinic acetylcholine receptor M₄.^{[1] [2] [3]} It is used in scientific research for studying the effects of the different muscarinic receptor subtypes in the body and brain.^{[4] [5] [6] [7]}

See also

• PD-0298029

Notes and References

1. Olianas MC, Onali P . PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP . Life Sciences . 65 . 21 . 2233–40 . 1999 . 10576595 . 10.1016/S0024-3205(99)00488-9.
2. Varoli L, Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Bedini A, Fazio N, Spampinato S . Diphenidol-related diamines as novel muscarinic M4 receptor antagonists . Bioorganic & Medicinal Chemistry Letters . 18 . 9 . 2972–6 . May 2008 . 18395442 . 10.1016/j.bmcl.2008.03.061 .
3. Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD . Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors . Journal of Medicinal Chemistry . 45 . 14 . 3094–102 . July 2002 . 12086495 . 10.1021/jm011116o.
4. Pujol Lereis VA, Hita FJ, Gobbi MD, Verdi MG, Rodriguez MC, Rothlin RP . Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein . . 147 . 5 . 516–23 . March 2006 . 16444291 . 1616972 . 10.1038/sj.bjp.0706654 .
5. Hogan K, Markos F . Muscarinic type 1 receptors mediate part of nitric oxide's vagal facilitatory effect in the isolated innervated rat right atrium . Nitric Oxide: Biology and Chemistry . 16 . 1 . 110–7 . February 2007 . 16843016 . 10.1016/j.niox.2006.05.005 .
6. Myslivecek J, Klein M, Novakova M, Ricny J . The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles . Naunyn-Schmiedeberg's Archives of Pharmacology . 378 . 1 . 103–16 . July 2008 . 18443764 . 10.1007/s00210-008-0285-8 .
7. Lau BK, Vaughan CW . Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray . Molecular Pharmacology . 74 . 5 . 1392–8 . November 2008 . 18678620 . 10.1124/mol.108.045872 .