PD-0298029 explained

PD-0298029 is a drug which acts as a selective antagonist for the muscarinic acetylcholine receptor M₄. It was developed for the treatment of Parkinson's disease, but poor bioavailability and rapid metabolism in animal studies have meant its use is largely limited to in vitro research into the M₄ and other muscarinic receptors.^{[1] [2] [3]}

See also

• PD-102,807

Notes and References

1. Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD . Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors . Journal of Medicinal Chemistry . 45 . 14 . 3094–102 . July 2002 . 12086495 . 10.1021/jm011116o.
2. Boehme TM, Angelli-Szafran CE, Corinne E, Hallak H and Schwarz RD. Analogs of M4 selective synthetic muscarinic receptor antagonists: Synthesis, binding and pharmacokinetic properties. Medicinal Chemistry Research. 2002; 11(8):423–433.
3. Progress in Medicinal Chemistry 43. (2005). Chapter 4, Muscarinic Receptor Subtype Pharmacology and Physiology, by Richard M Eglen. pp 128-129.