PCPr explained

PCPr is an arylcyclohexylamine dissociative anesthetic drug with hallucinogenic and stimulant effects. It is around the same potency as phencyclidine, although slightly less potent than the ethyl homologue eticyclidine,^[1] and has reportedly been sold as a designer drug in Germany and other European countries since the late 1990s.^{[2] [3]}

Several other related derivatives have also been encountered, with the n-propyl group of PCPr replaced by a 2-methoxyethyl, 2-ethoxyethyl or 3-methoxypropyl group to form PCMEA, PCEEA and PCMPA respectively.^{[4] [5] [6]}

Notes and References

1. MADDOX VH, GODEFROI EF, PARCELL RF . The Synthesis of Phencyclidine and Other 1-Arylcyclohexylamines . Journal of Medicinal Chemistry . 8 . 2. 230–5 . March 1965 . 14332667 . 10.1021/jm00326a019.
2. Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH . Metabolism and toxicological detection of a new designer drug, N-(1-phenylcyclohexyl)propanamine, in rat urine using gas chromatography-mass spectrometry . Journal of Chromatography A . 1186 . 1–2 . 380–90 . April 2008 . 18035363 . 10.1016/j.chroma.2007.11.002 .
3. http://scidok.sulb.uni-saarland.de/volltexte/2009/2077/pdf/Sauer_Dissertation_final_nach_Kolloq_eingereicht_ohne_Papers_ohne_Einband.pdf Christoph Sauer. Phencyclidine Derivatives – A new Class of Designer Drugs. Studies on the Metabolism and Toxicological Analysis. Universität des Saarlandes, 2008
4. Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH . New designer drugs N-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA) and N-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA): Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques . Journal of Mass Spectrometry . 43 . 3 . 305–16 . March 2008 . 17968862 . 10.1002/jms.1312 . 2008JMSp...43..305S .
5. Sauer C, Peters FT, Schwaninger AE, Meyer MR, Maurer HH . Investigations on the cytochrome P450 (CYP) isoenzymes involved in the metabolism of the designer drugs N-(1-phenyl cyclohexyl)-2-ethoxyethanamine and N-(1-phenylcyclohexyl)-2-methoxyethanamine . . 77 . 3 . 444–50 . February 2009 . 19022226 . 10.1016/j.bcp.2008.10.024 .
6. Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH . Metabolism and toxicological detection of the designer drug N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA) in rat urine using gas chromatography-mass spectrometry . Forensic Science International . 181 . 1–3 . 47–51 . October 2008 . 18922655 . 10.1016/j.forsciint.2008.09.001 .