PCOLCE explained

Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene.^{[1] [2] [3]}

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens activity.

Further reading

• Takahara K, Kessler E, Biniaminov L, etal . Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE) . J. Biol. Chem. . 269 . 42 . 26280–26285 . 1994 . 10.1016/S0021-9258(18)47191-8 . 7523404 . free .
• Scott IC, Clark TG, Takahara K, etal . Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein . Genomics . 55 . 2 . 229–234 . 1999 . 9933570 . 10.1006/geno.1998.5663 .
• Mott JD, Thomas CL, Rosenbach MT, etal . Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor . J. Biol. Chem. . 275 . 2 . 1384–1390 . 2000 . 10625689 . 10.1074/jbc.275.2.1384 . free .
• Ricard-Blum S, Bernocco S, Font B, etal . Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1 . J. Biol. Chem. . 277 . 37 . 33864–33869 . 2002 . 12105202 . 10.1074/jbc.M205018200 . free .
• Ligon AH, Scott IC, Takahara K, etal . PCOLCE deletion and expression analyses in uterine leiomyomata . Cancer Genet. Cytogenet. . 137 . 2 . 133–137 . 2002 . 12393284 . 10.1016/S0165-4608(02)00547-2 .
• Steiglitz BM, Keene DR, Greenspan DS . PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1 . J. Biol. Chem. . 277 . 51 . 49820–49830 . 2003 . 12393877 . 10.1074/jbc.M209891200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bernocco S, Steiglitz BM, Svergun DI, etal . Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein . J. Biol. Chem. . 278 . 9 . 7199–7205 . 2003 . 12486138 . 10.1074/jbc.M210857200 . free .
• Liepinsh E, Banyai L, Pintacuda G, etal . NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding . J. Biol. Chem. . 278 . 28 . 25982–25989 . 2003 . 12670942 . 10.1074/jbc.M302734200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Petropoulou V, Garrigue-Antar L, Kadler KE . Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1) . J. Biol. Chem. . 280 . 24 . 22616–22623 . 2005 . 15817489 . 10.1074/jbc.M413468200 . free .
• Ge G, Zhang Y, Steiglitz BM, Greenspan DS . Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains . J. Biol. Chem. . 281 . 16 . 10786–10798 . 2006 . 16507574 . 10.1074/jbc.M511111200 . free .
• Blanc G, Font B, Eichenberger D, etal . Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity . J. Biol. Chem. . 282 . 23 . 16924–16933 . 2007 . 17446170 . 10.1074/jbc.M701610200 . free. https://web.archive.org/web/20180723232756/http://www.jbc.org/content/282/23/16924.full.pdf. 2018-07-23.

Notes and References

1. Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS . Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein . Genomics . 31 . 2 . 253–256 . Mar 1997 . 8824813 . 10.1006/geno.1996.0043 .
2. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A . Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes . Genome Res . 8 . 10 . 1060–1073 . Dec 1998 . 9799793 . 310788 . 10.1101/gr.8.10.1060.
3. Web site: Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer.