PCGF6 explained

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.^{[1] [2]}

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Kanno M, Hasegawa M, Ishida A, etal . mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. . EMBO J. . 14 . 22 . 5672–8 . 1996 . 8521824 . 10.1002/j.1460-2075.1995.tb00254.x. 394682 .
• Trimarchi JM, Fairchild B, Wen J, Lees JA . The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 4 . 1519–24 . 2001 . 11171983 . 10.1073/pnas.041597698 . 29289 . free .
• Suzuki M, Mizutani-Koseki Y, Fujimura Y, etal . Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. . Development . 129 . 18 . 4171–83 . 2002 . 10.1242/dev.129.18.4171 . 12183370 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Zhong N, Radu G, Ju W, Brown WT . Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C. . Biochem. Biophys. Res. Commun. . 338 . 2 . 855–61 . 2006 . 16248985 . 10.1016/j.bbrc.2005.10.020 .
• Lee MG, Norman J, Shilatifard A, Shiekhattar R . Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. . Cell . 128 . 5 . 877–87 . 2007 . 17320162 . 10.1016/j.cell.2007.02.004 . 6519228 . free .

Notes and References

1. Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H . MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation . Genes Cells . 7 . 8 . 835–50 . Aug 2002 . 12167161 . 10.1046/j.1365-2443.2002.00565.x . 2027.42/72663 . 23060582 . free .
2. Web site: Entrez Gene: PCGF6 polycomb group ring finger 6.