PCGEM1 explained
| Prostate-specific transcript 1 |
| Symbol: | PCGEM1 |
| Rfam: | RF01981 |
| Rna Type: | Gene |
| Tax Domain: | Eukaryota |
Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer.[1] [2] In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.[3]
PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.[4]
See also
Further reading
- Ifere GO, Barr E, Equan A, etal . Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines. . Cancer Detect. Prev. . 32 . 4 . 319–328 . 2009 . 19186008 . 10.1016/j.cdp.2008.12.002 .
- Enciso-Mora V, Hosking FJ, Houlston RS . Risk of breast and prostate cancer is not associated with increased homozygosity in outbred populations. . Eur. J. Hum. Genet. . 18 . 8 . 909–914 . 2010 . 20407466 . 10.1038/ejhg.2010.53 . 2987391.
- Romanuik TL, Wang G, Morozova O, Delaney A, Marra MA, Sadar MD . LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer . BMC Med. Genom. . 3 . 43 . 2010 . 20868494 . 2956710 . 10.1186/1755-8794-3-43 . free .
- Ifere GO, Ananaba GA . Prostate cancer gene expression marker 1 (PCGEM1): a patented prostate- specific non-coding gene and regulator of prostate cancer progression . Recent Pat DNA Gene Seq . 3 . 3 . 151–163 . November 2009 . 19891595 . 10.2174/187221509789318360.
Notes and References
- Srikantan V, Zou Z, Petrovics G, etal . PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer . Proc. Natl. Acad. Sci. U.S.A. . 97 . 22 . 12216–12221 . October 2000 . 11050243 . 17321 . 10.1073/pnas.97.22.12216 . 2000PNAS...9712216S . free .
- Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H . Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue . Can J Urol . 13 . 1 . 2967–2974 . February 2006 . 16515751 .
- Petrovics G, Zhang W, Makarem M, etal . Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients . Oncogene . 23 . 2 . 605–611 . January 2004 . 14724589 . 10.1038/sj.onc.1207069 . free .
- Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S . Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1 . DNA Cell Biol. . 25 . 3 . 135–141 . March 2006 . 16569192 . 10.1089/dna.2006.25.135 .
