PCDH18 explained
Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.[1] [2] [3]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.
Further reading
- Suzuki ST . Recent progress in protocadherin research . Exp. Cell Res. . 261 . 1 . 13–8 . 2000 . 11082270 . 10.1006/excr.2000.5039 .
- Yagi T, Takeichi M . Cadherin superfamily genes: functions, genomic organization, and neurologic diversity . Genes Dev. . 14 . 10 . 1169–80 . 2000 . 10817752 . 10.1101/gad.14.10.1169. 44844497 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Homayouni R, Rice DS, Curran T . Disabled-1 interacts with a novel developmentally regulated protocadherin . Biochem. Biophys. Res. Commun. . 289 . 2 . 539–47 . 2002 . 11716507 . 10.1006/bbrc.2001.5998 .
- Nagase T, Kikuno R, Nakayama M, etal . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 4 . 273–81 . 2001 . 10997877 . 10.1093/dnares/7.4.271. free .
- Wu Q, Maniatis T . Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3124–9 . 2000 . 10716726 . 10.1073/pnas.060027397 . 16203 . free .
Notes and References
- Nollet F, Kools P, van Roy F . Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members . J Mol Biol . 299 . 3 . 551–72 . Jul 2000 . 10835267 . 10.1006/jmbi.2000.3777 .
- Wolverton T, Lalande M . Identification and characterization of three members of a novel subclass of protocadherins . Genomics . 76 . 1–3 . 66–72 . Sep 2001 . 11549318 . 10.1006/geno.2001.6592 .
- Web site: Entrez Gene: PCDH18 protocadherin 18.