PCDH10 explained

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.^{[1] [2]}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.

Further reading

• Yagi T, Takeichi M . Cadherin superfamily genes: functions, genomic organization, and neurologic diversity . Genes Dev. . 14 . 10 . 1169–80 . 2000 . 10817752 . 10.1101/gad.14.10.1169. 44844497 . free .
• Cross SH, Charlton JA, Nan X, Bird AP . Purification of CpG islands using a methylated DNA binding column . Nat. Genet. . 6 . 3 . 236–44 . 1994 . 8012384 . 10.1038/ng0394-236 . 12847618 .
• Wu Q, Maniatis T . A striking organization of a large family of human neural cadherin-like cell adhesion genes . Cell . 97 . 6 . 779–90 . 1999 . 10380929 . 10.1016/S0092-8674(00)80789-8 . 6014717 . free .
• Wu Q, Maniatis T . Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3124–9 . 2000 . 10716726 . 10.1073/pnas.060027397 . 16203 . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . vanc. Kikuno R . Ishikawa KI . 3 . Hirosawa . M . Ohara . O . free.
• Wu Q . Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters . Genome Res. . 11 . 3 . 389–404 . 2001 . 11230163 . 10.1101/gr.167301 . 311048 . vanc. Zhang T . Cheng JF . 3 . Kim . Y . Grimwood . J . Schmutz . J . Dickson . M . Noonan . JP . Zhang . MQ .
• Wolverton T, Lalande M . Identification and characterization of three members of a novel subclass of protocadherins . Genomics . 76 . 1–3 . 66–72 . 2001 . 11549318 . 10.1006/geno.2001.6592 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ying J . Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation . Oncogene . 25 . 7 . 1070–80 . 2006 . 16247458 . 10.1038/sj.onc.1209154 . vanc. Li H . Seng TJ . 3 . Langford . C . Srivastava . G . Tsao . S W . Putti . T . Murray . P . Chan . A T C . 11573872 .

Notes and References

1. Nollet F, Kools P, van Roy F . Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members . J Mol Biol . 299 . 3 . 551–72 . Jul 2000 . 10835267 . 10.1006/jmbi.2000.3777 .
2. Web site: Entrez Gene: PCDH10 protocadherin 10.