PCBP3 explained

Poly(rC)-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene.^{[1] [2]}

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene.

Further reading

• Makeyev AV, Liebhaber SA . The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. . RNA . 8 . 3 . 265–78 . 2002 . 12003487 . 10.1017/S1355838202024627 . 1370249 .
• Kiledjian M, Wang X, Liebhaber SA . Identification of two KH domain proteins in the alpha-globin mRNP stability complex. . EMBO J. . 14 . 17 . 4357–64 . 1995 . 7556077 . 10.1002/j.1460-2075.1995.tb00110.x. 394520 .
• Hattori M, Fujiyama A, Taylor TD, etal . The DNA sequence of human chromosome 21. . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . free .
• Makeyev AV, Eastmond DL, Liebhaber SA . Targeting a KH-domain protein with RNA decoys. . RNA . 8 . 9 . 1160–73 . 2002 . 12358435 . 10.1017/S135583820202808X . 1370330 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chkheidze AN, Liebhaber SA . A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. . Mol. Cell. Biol. . 23 . 23 . 8405–15 . 2003 . 14612387 . 10.1128/MCB.23.23.8405-8415.2003 . 262676 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Hu YH, Warnatz HJ, Vanhecke D, etal . Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. . BMC Genomics . 7. 155 . 2006 . 16780588 . 10.1186/1471-2164-7-155 . 1526728 . free .

Notes and References

1. Makeyev AV, Liebhaber SA . Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins . Genomics . 67 . 3 . 301–16 . Sep 2000 . 10936052 . 10.1006/geno.2000.6244 .
2. Web site: Entrez Gene: PCBP3 poly(rC) binding protein 3.