PASTA domain explained

Symbol:	PASTA
PASTA domain
Pfam:	PF03793
Interpro:	IPR005543
Smart:	PASTA
Prosite:	PDOC51178
Scop:	1rp5
Cdd:	cd06573
Pdb:	A:694-750, A:694-750, B:694-750, A:694-750, A:694-750

The PASTA domain is a small protein domain that can bind to the beta-lactam ring portion of various β-lactam antibiotics.^[1] The domain was initially discovered in 2002 by Yeats and colleagues as a region of sequence similarity found in penicillin binding proteins and PknB-like kinases found in some bacteria. The name is an acronym derived from PBP and Serine/Threonine kinase Associated domain.

Structure

The PASTA domain adopts a structure composed of an alpha-helix followed by three beta strands. Recent structural studies show that the extracellular region of PknB (protein kinase B) that is composed of four PASTA domains shows a linear arrangement of the domains.^[2]

Species distribution

PASTA domains are found in a variety of bacterial species including gram-positive Bacillota and Actinomycetota.

Notes and References

1. Yeats C, Finn RD, Bateman A . The PASTA domain: a beta-lactam-binding domain . Trends Biochem. Sci. . 27 . 9 . 438–440 . September 2002 . 12217513 . 10.1016/s0968-0004(02)02164-3.
2. Barthe P, Mukamolova GV, Roumestand C, Cohen-Gonsaud M . The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation . Structure . 18 . 5 . 606–15 . May 2010 . 20462494 . 10.1016/j.str.2010.02.013 . free .