PASK explained

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.^{[1] [2] [3] [4]}

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Nagase T, Seki N, Tanaka A, etal . Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 2 . 4 . 167–74, 199–210 . 1996 . 8590280 . 10.1093/dnares/2.4.167 . free .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Ceulemans H, Van Eynde A, Pérez-Callejón E, etal . Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1 . Eur. J. Biochem. . 262 . 1 . 36–42 . 1999 . 10231361 . 10.1046/j.1432-1327.1999.00344.x . free .
• Amezcua CA, Harper SM, Rutter J, Gardner KH . Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation . Structure . 10 . 10 . 1349–61 . 2003 . 12377121 . 10.1016/S0969-2126(02)00857-2 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Eckhardt K, Troger J, Reissmann J, etal . Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1 . Cell. Physiol. Biochem. . 20 . 1–4 . 227–40 . 2007 . 17595531 . 10.1159/000104169 . free .
• Kikani CK, Antonysamy SA, Bonanno JB, etal . Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation . J. Biol. Chem. . 285 . 52 . 41034–43 . 2010 . 20943661 . 10.1074/jbc.M110.157594 . 3003402. free .

Notes and References

1. Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH . Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors . Biochem Biophys Res Commun . 288 . 4 . 757–64 . Nov 2001 . 11688972 . 10.1006/bbrc.2001.5840 . 2018-12-22 . 2013-11-02 . https://web.archive.org/web/20131102203743/http://www.zora.uzh.ch/1428/1/Hofer_a2001MaV.pdf . dead .
2. Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL . PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase . Proc Natl Acad Sci U S A . 98 . 16 . 8991–6 . Aug 2001 . 11459942 . 55361 . 10.1073/pnas.161284798 . 2001PNAS...98.8991R . free .
3. da Silva Xavier G, Rutter J, Rutter GA . Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose . Proc Natl Acad Sci U S A . 101 . 22 . 8319–24 . Jun 2004 . 15148392 . 420392 . 10.1073/pnas.0307737101 . 2004PNAS..101.8319D . free .
4. Web site: Entrez Gene: PASK PAS domain containing serine/threonine kinase.