PASD1 explained

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.^{[1] [2] [3]}

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.^{[4] [5]}

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–1795 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Reports . 1 . 3 . 287–292 . September 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, Wells JW, Banham AH, Mufti GJ . 6 . Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia . Biochemical and Biophysical Research Communications . 335 . 4 . 1293–1304 . October 2005 . 16112646 . 10.1016/j.bbrc.2005.08.024 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH . Serologic detection of diffuse large B-cell lymphoma-associated antigens . International Journal of Cancer . 110 . 4 . 563–569 . July 2004 . 15122589 . 10.1002/ijc.20170 . free .
2. Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH . A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein . British Journal of Cancer . 91 . 1 . 141–149 . July 2004 . 15162151 . 2364759 . 10.1038/sj.bjc.6601875 .
3. Web site: Entrez Gene: PASD1 PAS domain containing 1.
4. Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL . Cancer/Testis Antigen PASD1 Silences the Circadian Clock . Molecular Cell . 58 . 5 . 743–754 . June 2015 . 25936801 . 4458219 . 10.1016/j.molcel.2015.03.031 .
5. Web site: Greenwood V . 15 September 2015 . How the Body's Trillions of Clocks Keep Time . Quanta Magazine.