PARVB explained

Beta-parvin is a protein that in humans is encoded by the PARVB gene.^{[1] [2] [3]}

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]^[4]

Further reading

• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Yamaji S, Suzuki A, Sugiyama Y, etal . A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. . J. Cell Biol. . 153 . 6 . 1251–64 . 2001 . 11402068 . 10.1083/jcb.153.6.1251 . 2192033 .
• Korenbaum E, Olski TM, Noegel AA . Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. . Gene . 279 . 1 . 69–79 . 2002 . 11722847 . 10.1016/S0378-1119(01)00743-0 .
• Yamaji S, Suzuki A, Kanamori H, etal . Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation. . Biochem. Biophys. Res. Commun. . 297 . 5 . 1324–31 . 2002 . 12372433 . 10.1016/S0006-291X(02)02381-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Rosenberger G, Jantke I, Gal A, Kutsche K . Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. . Hum. Mol. Genet. . 12 . 2 . 155–67 . 2003 . 12499396 . 10.1093/hmg/ddg019 . free .
• Collins JE, Goward ME, Cole CG, etal . Reevaluating human gene annotation: a second-generation analysis of chromosome 22. . Genome Res. . 13 . 1 . 27–36 . 2003 . 12529303 . 10.1101/gr.695703 . 430954 .
• Mishima W, Suzuki A, Yamaji S, etal . The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. . Genes Cells . 9 . 3 . 193–204 . 2004 . 15005707 . 10.1111/j.1356-9597.2004.00717.x . free .
• Yamaji S, Suzuki A, Kanamori H, etal . Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. . J. Cell Biol. . 165 . 4 . 539–51 . 2004 . 15159419 . 10.1083/jcb.200308141 . 2172344 .
• Zhang Y, Chen K, Tu Y, Wu C . Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. . J. Biol. Chem. . 279 . 40 . 41695–705 . 2004 . 15284246 . 10.1074/jbc.M401563200 . free .
• Mongroo PS, Johnstone CN, Naruszewicz I, etal . Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. . Oncogene . 23 . 55 . 8959–70 . 2004 . 15467740 . 10.1038/sj.onc.1208112 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Matsuda C, Kameyama K, Tagawa K, etal . Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. . J. Neuropathol. Exp. Neurol. . 64 . 4 . 334–40 . 2005 . 15835269 . 10.1093/jnen/64.4.334. free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
2. Olski TM, Noegel AA, Korenbaum E . Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily . J Cell Sci . 114 . Pt 3 . 525–38 . Feb 2001 . 10.1242/jcs.114.3.525 . 11171322 .
3. Web site: Entrez Gene: PARVB parvin, beta.
4. Web site: Entrez Gene: PARVB parvin, beta.