PARP10 explained

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.^{[1] [2]}

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]^[3]

Further reading

• Chou HY, Chou HT, Lee SC . CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). . J. Biol. Chem. . 281 . 22 . 15201–7 . 2006 . 16455663 . 10.1074/jbc.M506745200 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Yu M, Schreek S, Cerni C, etal . PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. . Oncogene . 24 . 12 . 1982–93 . 2005 . 15674325 . 10.1038/sj.onc.1208410 . 13330538 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Ame JC, Spenlehauer C, de Murcia G . The PARP superfamily . BioEssays . 26 . 8 . 882–93 . Jul 2004 . 15273990 . 10.1002/bies.20085 . 25024719 . free .
2. Web site: Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10.
3. Web site: Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10.