PARD3B explained

Partitioning defective 3 homolog B is a protein that in humans is encoded by the PARD3B gene.^{[1] [2] [3]}

Interactions

PARD3B has been shown to interact with Mothers against decapentaplegic homolog 3.^[4]

Further reading

• Izaki T, Kamakura S, Kohjima M, Sumimoto H . Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3 . Biochem. Biophys. Res. Commun. . 341 . 4 . 1001–6 . 2006 . 16458856 . 10.1016/j.bbrc.2006.01.050 .
• Benzinger A, Muster N, Koch HB, etal . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Izaki T, Kamakura S, Kohjima M, Sumimoto H . Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein . Biochem. Biophys. Res. Commun. . 329 . 1 . 211–8 . 2005 . 15721295 . 10.1016/j.bbrc.2005.01.115 .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Warner DR, Pisano MM, Roberts EA, Greene RM . Identification of three novel Smad binding proteins involved in cell polarity . FEBS Lett. . 539 . 1–3 . 167–73 . 2003 . 12650946 . 10.1016/S0014-5793(03)00155-8 . 7429554 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gao L, Macara IG, Joberty G . Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties . Gene . 294 . 1–2 . 99–107 . 2003 . 12234671 . 10.1016/S0378-1119(02)00681-9 .

Notes and References

1. Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE . A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 . Nat Genet . 29 . 2 . 166–73 . Oct 2001 . 11586298 . 10.1038/ng1001-166 . 52828189 .
2. Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H . PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions . Biochem Biophys Res Commun . 299 . 4 . 641–6 . Dec 2002 . 12459187 . 10.1016/S0006-291X(02)02698-0 .
3. Web site: Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans).
4. Warner . Dennis R . Pisano M Michele . Roberts Emily A . Greene Robert M . Mar 2003 . Identification of three novel Smad binding proteins involved in cell polarity . FEBS Lett. . 539 . 1–3 . 167–73 . Netherlands. 0014-5793. 12650946 . 10.1016/S0014-5793(03)00155-8 . 7429554 . free .