PAR1 (gene) explained

Prader-Willi/Angelman region-1, also known as PWAR1, is an exon of the lncRNA Small nucleolar RNA host gene 14 (SNHG14).^[1]

Further reading

• Sutcliffe JS . Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region . Nat. Genet. . 8 . 1 . 52–8 . 1995 . 7987392 . 10.1038/ng0994-52 . vanc. Nakao M . Christian S . 3 . Örstavik . Karen H. . Tommerup . Niels . Ledbetter . David H. . Beaudet . Arthur L. . 31504627 .
• Schulze A . Exclusion of SNRPN as a major determinant of Prader-Willi syndrome by a translocation breakpoint . Nat. Genet. . 12 . 4 . 452–4 . 1996 . 8630505 . 10.1038/ng0496-452 . vanc. Hansen C . Skakkebaek NE . 3 . Brøndum-Nielsen . Karen . Ledbetter . David H. . Tommerup . Niels . 22259236 .
• Christian SL . Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb . Genome Res. . 8 . 2 . 146–57 . 1998 . 9477342 . 10.1101/gr.8.2.146. 310691 . vanc. Bhatt NK . Martin SA . 3 . Sutcliffe . JS . Kubota . T . Huang . B . Mutirangura . A . Chinault . AC . Beaudet . AL .
• Wirth J . A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15 . Hum. Mol. Genet. . 10 . 3 . 201–10 . 2001 . 11159938 . 10.1093/hmg/10.3.201 . vanc. Back E . Hüttenhofer A . 3 . Nothwang . HG . Lich . C . Gross . S . Menzel . C . Schinzel . A . Kioschis . P . free .
• Dorsam RT, Tuluc M, Kunapuli SP . Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets . J. Thromb. Haemost. . 2 . 5 . 804–12 . 2005 . 15099288 . 10.1111/j.1538-7836.2004.00692.x . 20124469 . free .
• Nakayama T . Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells . Biochem. Pharmacol. . 68 . 1 . 23–32 . 2004 . 15183114 . 10.1016/j.bcp.2004.03.005 . vanc. Hirano K . Hirano M . 3 . Nishimura . J . Kuga . H . Nakamura . K . Takahashi . S . Kanaide . H .
• Shi X . Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis . Mol. Cancer Res. . 2 . 7 . 395–402 . 2005 . 15280447 . vanc. Gangadharan B . Brass LF . 3 . Ruf . W . Mueller . BM . 10.1158/1541-7786.395.2.7 . 31329993 . free .
• Heider I . PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism . Oncol. Res. . 14 . 10 . 475–82 . 2005 . 15559761 . 10.3727/0965040042380496. vanc. Schulze B . Oswald E . 3 . Henklein . P . Scheele . J . Kaufmann . R .
• Tantivejkul K . PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism . J. Cell. Biochem. . 96 . 3 . 641–52 . 2005 . 16052512 . 10.1002/jcb.20533 . vanc. Loberg RD . Mawocha SC . 3 . Day . Lashon L. . John . Lauren St. . Pienta . Brian A. . Rubin . Mark A. . Pienta . Kenneth J. . 2027.42/48764 . 34707839 . free .

Notes and References

1. Web site: Entrez Gene: PAR1 Prader-Willi/Angelman region-1.