Adiponectin receptor 2 explained
Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[1] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[2]
Structure
Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[1]
Function
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[3]
Ligands
Agonists
Peptide
Non-peptide
Antagonists
Peptide
See also
Notes and References
- Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T . Cloning of adiponectin receptors that mediate antidiabetic metabolic effects . Nature . 423 . 6941 . 762–9 . June 2003 . 12802337 . 10.1038/nature01705 . 2003Natur.423..762Y . 52860797 .
- Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD . PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif . Journal of Molecular Evolution . 61 . 3 . 372–80 . September 2005 . 16044242 . 10.1007/s00239-004-0375-2 . 2005JMolE..61..372T . 31473802 .
- https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups
- Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S . Development of second generation peptides modulating cellular adiponectin receptor responses . Frontiers in Chemistry . 2 . 93 . 2014 . 25368867 . 4201147 . 10.3389/fchem.2014.00093 . 2014FrCh....2...93O . free .
- Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T . A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity . Nature . 503 . 7477 . 493–9 . November 2013 . 24172895 . 10.1038/nature12656 . 2013Natur.503..493O . 4447039 .
- Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z . Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay . PLOS ONE . 8 . 5 . e63354 . 2013 . 23691032 . 3653934 . 10.1371/journal.pone.0063354 . 2013PLoSO...863354S . free .
