Pappalysin-2 Explained

Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.^{[1] [2] [3]}

Further reading

• Firth SM, Baxter RC . Cellular actions of the insulin-like growth factor binding proteins. . Endocr. Rev. . 23 . 6 . 824–54 . 2003 . 12466191 . 10.1210/er.2001-0033 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Page NM, Butlin DJ, Lomthaisong K, Lowry PJ . The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant. . Placenta . 22 . 8–9 . 681–7 . 2001 . 11597188 . 10.1053/plac.2001.0709 .
• Ständker L, Wobst P, Mark S, Forssmann WG . Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5 . FEBS Lett. . 441 . 2 . 281–6 . 1999 . 9883900 . 10.1016/S0014-5793(98)01497-5 . free .

Notes and References

1. Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H . Pregnancy-associated plasma protein-E (PAPP-E) . Biochim Biophys Acta . 1493 . 3 . 356–62 . Nov 2000 . 11018262 . 10.1016/s0167-4781(00)00195-0.
2. Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C . Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase . J Biol Chem . 276 . 24 . 21849–53 . Jun 2001 . 11264294 . 10.1074/jbc.M102191200 . free .
3. Web site: Entrez Gene: PAPPA2 pappalysin 2.