PAPOLG explained

Poly(A) polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene.^[1]

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Topalian SL, Kaneko S, Gonzales MI, etal . Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. . Mol. Cell. Biol. . 21 . 16 . 5614–23 . 2001 . 11463842 . 10.1128/MCB.21.16.5614-5623.2001 . 87282 .
• Kyriakopoulou CB, Nordvarg H, Virtanen A . A novel nuclear human poly(A) polymerase (PAP), PAP gamma. . J. Biol. Chem. . 276 . 36 . 33504–11 . 2001 . 11431479 . 10.1074/jbc.M104599200 . free .
• Perumal K, Sinha K, Henning D, Reddy R . Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. . J. Biol. Chem. . 276 . 24 . 21791–6 . 2001 . 11287430 . 10.1074/jbc.M101905200 . free .
• Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ . Tat-dependent occlusion of the HIV poly(A) site. . EMBO J. . 12 . 5 . 2119–28 . 1993 . 8491200 . 10.1002/j.1460-2075.1993.tb05860.x. 413433 .

Notes and References

1. Web site: Entrez Gene: PAPOLG poly(A) polymerase gamma.