PAIP2 explained

Polyadenylate-binding protein-interacting protein 2 is a protein that in humans is encoded by the PAIP2 gene.^{[1] [2] [3]}

Interactions

PAIP2 has been shown to interact with PABPC1.^[4]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Kozlov G, Trempe JF, Khaleghpour K, Kahvejian A, Ekiel I, Gehring K . Structure and function of the C-terminal PABC domain of human poly(A)-binding protein . Proc. Natl. Acad. Sci. U.S.A. . 98 . 8 . 4409–13 . 2001 . 11287632 . 31848 . 10.1073/pnas.071024998 . free .
• Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin YV, Imataka H, O'Connor-McCourt M, Sonenberg N . Dual interactions of the translational repressor Paip2 with poly(A) binding protein . Mol. Cell. Biol. . 21 . 15 . 5200–13 . 2001 . 11438674 . 87244 . 10.1128/MCB.21.15.5200-5213.2001 .
• Gouyon F, Onesto C, Dalet V, Pages G, Leturque A, Brot-Laroche E . Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2 . Biochem. J. . 375 . Pt 1 . 167–74 . 2003 . 12820898 . 1223656 . 10.1042/BJ20030661 .
• Onesto C, Berra E, Grépin R, Pagès G . Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA . J. Biol. Chem. . 279 . 33 . 34217–26 . 2004 . 15175342 . 10.1074/jbc.M400219200 . free .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415-8 . 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N . Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2 . EMBO J. . 25 . 9 . 1934–44 . 2006 . 16601676 . 1456944 . 10.1038/sj.emboj.7601079 .

Notes and References

1. Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N . Translational repression by a novel partner of human poly(A) binding protein, Paip2 . Mol. Cell . 7 . 1 . 205–16 . Feb 2001 . 11172725 . 10.1016/S1097-2765(01)00168-X . free .
2. Berlanga JJ, Baass A, Sonenberg N . Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B . RNA . 12 . 8 . 1556–68 . Jul 2006 . 16804161 . 1524897 . 10.1261/rna.106506 .
3. Web site: Entrez Gene: PAIP2 poly(A) binding protein interacting protein 2.
4. Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin YV, Imataka H, O'Connor-McCourt M, Sonenberg N . Dual interactions of the translational repressor Paip2 with poly(A) binding protein . Mol. Cell. Biol. . 21 . 15 . 5200–13 . Aug 2001 . 11438674 . 87244 . 10.1128/MCB.21.15.5200-5213.2001 .