PAIP1 explained

Polyadenylate-binding protein-interacting protein 1 is a protein that in humans is encoded by the PAIP1 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Interactions

PAIP1 has been shown to interact with PABPC1.^[4]

Further reading

• Gray NK, Coller JM, Dickson KS, Wickens M . Multiple portions of poly(A)-binding protein stimulate translation in vivo . EMBO J. . 19 . 17 . 4723–33 . 2000 . 10970864 . 302064 . 10.1093/emboj/19.17.4723 .
• Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB . A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex . Cell . 103 . 1 . 29–40 . 2000 . 11051545 . 10.1016/S0092-8674(00)00102-1 . 18135412 . free .
• Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N . Translational repression by a novel partner of human poly(A) binding protein, Paip2 . Mol. Cell . 7 . 1 . 205–16 . 2001 . 11172725 . 10.1016/S1097-2765(01)00168-X . free .
• Deo RC, Sonenberg N, Burley SK . X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein . Proc. Natl. Acad. Sci. U.S.A. . 98 . 8 . 4414–9 . 2001 . 11287654 . 31849 . 10.1073/pnas.071552198 . free .
• Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N . Paip1 interacts with poly(A) binding protein through two independent binding motifs . Mol. Cell. Biol. . 22 . 11 . 3769–82 . 2002 . 11997512 . 133836 . 10.1128/MCB.22.11.3769-3782.2002 .
• Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM . Lineage-specific gene duplication and loss in human and great ape evolution . PLOS Biol. . 2 . 7 . E207 . 2004 . 15252450 . 449870 . 10.1371/journal.pbio.0020207 . free .

Notes and References

1. Craig AW, Haghighat A, Yu AT, Sonenberg N . Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation . Nature . 392 . 6675 . 520–3 . Apr 1998 . 9548260 . 10.1038/33198 . 1998Natur.392..520C . 10891925 .
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
3. Web site: Entrez Gene: PAIP1 poly(A) binding protein interacting protein 1.
4. Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N . Paip1 interacts with poly(A) binding protein through two independent binding motifs . Mol. Cell. Biol. . 22 . 11 . 3769–82 . Jun 2002 . 11997512 . 133836 . 10.1128/MCB.22.11.3769-3782.2002 .