1-alkyl-2-acetylglycerophosphocholine esterase explained

1-alkyl-2-acetylglycerophosphocholine esterase
Ec Number:	3.1.1.47
Cas Number:	76901-00-3
Go Code:	0003847

The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O

\rightleftharpoons 1-alkyl-sn-glycero-3-phosphocholine + acetate

The former is also known as platelet-activating factor. There are multiple enzymes with this function:

• Lipoprotein-associated phospholipase A2
• Platelet-activating factor acetylhydrolase 2, cytoplasmic
• Platelet-activating factor acetylhydrolase 1b: regulatory subunit 1, catalytic subunit 2, catalytic subunit 3

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes,,,,,, and .

References

• Blank ML, Lee T, Fitzgerald V, Snyder F . 1981 . A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid) . J. Biol. Chem. . 256 . 175 - 8 . 7451433 . 1 .