PAFAH1B3 explained

Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene.^{[1] [2]}

Interactions

PAFAH1B3 has been shown to interact with PAFAH1B1^[3] and LNX1.^[4]

See also

• PAFAH1B1
• PAFAH1B2

Further reading

• Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R . The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively . Genomics . 51 . 1 . 157–9 . Jul 1998 . 9693049 . 10.1006/geno.1998.5322 .
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G . Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development . Mechanisms of Development . 92 . 2 . 263–71 . Apr 2000 . 10727864 . 10.1016/S0925-4773(00)00242-2 . 2447495 .
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS . Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib . Protein Engineering . 14 . 7 . 513–9 . Jul 2001 . 11522926 . 10.1093/protein/14.7.513 . free .
• Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T . Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems . Biochemical and Biophysical Research Communications . 314 . 2 . 396–402 . Feb 2004 . 14733918 . 10.1016/j.bbrc.2003.12.108 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY . Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress . Biochemical and Biophysical Research Communications . 337 . 4 . 1308–18 . Dec 2005 . 16236267 . 10.1016/j.bbrc.2005.09.191 .

Notes and References

1. Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K . cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues . Biochemical and Biophysical Research Communications . 214 . 1 . 180–7 . Sep 1995 . 7669037 . 10.1006/bbrc.1995.2272 .
2. Web site: Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa.
3. Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G . Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development . Mechanisms of Development . 92 . 2 . 263–71 . Apr 2000 . 10727864 . 10.1016/S0925-4773(00)00242-2 . 2447495 .
4. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .