PAFAH1B2 explained

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.^{[1] [2] [3]}

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.^[4]

See also

• PAFAH1B1
• PAFAH1B3

Further reading

• Albrecht U, Abu-Issa R, Rätz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G . Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor . Developmental Biology . 180 . 2 . 579–93 . Dec 1996 . 8954729 . 10.1006/dbio.1996.0330 . free .
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G . Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development . Mechanisms of Development . 92 . 2 . 263–71 . Apr 2000 . 10727864 . 10.1016/S0925-4773(00)00242-2 . free .
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS . Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib . Protein Engineering . 14 . 7 . 513–9 . Jul 2001 . 11522926 . 10.1093/protein/14.7.513 . free .
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A . The human plasma proteome: a nonredundant list developed by combination of four separate sources . Molecular & Cellular Proteomics . 3 . 4 . 311–26 . Apr 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . free .
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B . Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis . Proteomics . 5 . 15 . 3876–84 . Oct 2005 . 16130169 . 10.1002/pmic.200401239 . 26007149 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG . Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample . Thrombosis and Haemostasis . 98 . 3 . 587–92 . Sep 2007 . 17849047 . 10.1160/th07-02-0134 . 7180897 .

Notes and References

1. Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K . Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I) . Biochemical and Biophysical Research Communications . 233 . 1 . 10–3 . Apr 1997 . 9144386 . 10.1006/bbrc.1997.6383 .
2. Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R . The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively . Genomics . 51 . 1 . 157–9 . Jul 1998 . 9693049 . 10.1006/geno.1998.5322 .
3. Web site: Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa.
4. Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G . Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development . Mechanisms of Development . 92 . 2 . 263–71 . Apr 2000 . 10727864 . 10.1016/S0925-4773(00)00242-2 . free .