PACSIN1 explained

Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I^{[1] [2]} is an enzyme that in humans is encoded by the PACSIN1 gene.^[3]

Interactions

PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).

A variety of interactions have been published:

• DNM1^{[4] [5] [6]}
• Huntingtin^[7]
• PACSIN2^{[6] [8]}
• PACSIN3^[6]

Further reading

• Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G . Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1 . Journal of Molecular Biology . 307 . 5 . 1329–39 . Apr 2001 . 11292345 . 10.1006/jmbi.2001.4572 .
• Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, McPherson PS . The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton . The Journal of Biological Chemistry . 276 . 28 . 26622–8 . Jul 2001 . 11352907 . 10.1074/jbc.M100591200 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)

Notes and References

1. Web site: PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [Homo sapiens (human)] - Gene - NCBI ]. 2024-08-04 . www.ncbi.nlm.nih.gov.
2. Web site: Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Mus musculus (house mouse)] - Gene - NCBI ]. 2024-08-04 . www.ncbi.nlm.nih.gov.
3. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M . PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family . Gene . 262 . 1–2 . 199–205 . Jan 2001 . 11179684 . 10.1016/S0378-1119(00)00531-X .
4. Qualmann B, Roos J, DiGregorio PJ, Kelly RB . Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein . Molecular Biology of the Cell . 10 . 2 . 501–513 . February 1999 . 9950691 . 25183 . 10.1091/mbc.10.2.501 . Suzanne R. . Pfeffer .
5. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N . A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis . The Journal of Biological Chemistry . 279 . 38 . 40091–9 . Sep 2004 . 15252009 . 10.1074/jbc.M404899200 . free .
6. Modregger J, Ritter B, Witter B, Paulsson M, Plomann M . All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis . Journal of Cell Science . 113 . 24. 4511–21 . Dec 2000 . 11082044 . 10.1242/jcs.113.24.4511.
7. Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M . PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains . Human Molecular Genetics . 11 . 21 . 2547–58 . Oct 2002 . 12354780 . 10.1093/hmg/11.21.2547.
8. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R .