P4HTM explained

Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene.^[1]

Function

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.

Further reading

• Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I . Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors . Biochem. Biophys. Res. Commun. . 296 . 2 . 343–9 . 2002 . 12163023 . 10.1016/s0006-291x(02)00862-8.
• Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J . Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor . J. Biol. Chem. . 278 . 33 . 30772–80 . 2003 . 12788921 . 10.1074/jbc.M304982200 . free .
• Pekkala M, Hieta R, Bergmann U, Kivirikko KI, Wierenga RK, Myllyharju J . The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues . J. Biol. Chem. . 279 . 50 . 52255–61 . 2004 . 15456751 . 10.1074/jbc.M410007200 . free .
• Hirota K, Semenza GL . Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases . Biochem. Biophys. Res. Commun. . 338 . 1 . 610–6 . 2005 . 16154531 . 10.1016/j.bbrc.2005.08.193 . free .
• Iwahashi M, Muragaki Y, Ino K . Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle . Reprod. Biol. Endocrinol. . 10 . 111 . 2012 . 23241241 . 3566935 . 10.1186/1477-7827-10-111 . free .

Notes and References

1. Web site: Entrez Gene: Prolyl 4-hydroxylase, transmembrane. 2017-10-03.