P2RY2 explained

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.^{[1] [2]}

The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[3]

See also

• P2Y receptor
• Denufosol, a P2Y₂ agonist

Further reading

• Tokuyama Y, Hara M, Jones EM, etal . Cloning of rat and mouse P2Y purinoceptors. . Biochem. Biophys. Res. Commun. . 211 . 1 . 211–8 . 1995 . 7779087 . 10.1006/bbrc.1995.1798 .
• Parr CE, Sullivan DM, Paradiso AM, etal . Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 26 . 13067 . 1995 . 7809171 . 10.1073/pnas.91.26.13067 . 45582 . free .
• Erb L, Lustig KD, Sullivan DM, etal . Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 22 . 10449–53 . 1993 . 8248130 . 10.1073/pnas.90.22.10449 . 47794 . 1993PNAS...9010449E . free .
• Dasari VR, Sandhu AK, Mills DC, etal . Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1. . Somat. Cell Mol. Genet. . 22 . 1 . 75–9 . 1996 . 8643996 . 10.1007/BF02374378 . 6509435 .
• Sullivan DM, Erb L, Anglade E, etal . Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells. . J. Neurosci. Res. . 49 . 1 . 43–52 . 1997 . 9211988 . 10.1002/(SICI)1097-4547(19970701)49:1<43::AID-JNR5>3.0.CO;2-D . 21044840 .
• Bogdanov Y, Rubino A, Burnstock G . Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart. . Life Sci. . 62 . 8 . 697–703 . 1998 . 9489506 . 10.1016/S0024-3205(97)01168-5 .
• Jin J, Dasari VR, Sistare FD, Kunapuli SP . Distribution of P2Y receptor subtypes on haematopoietic cells. . Br. J. Pharmacol. . 123 . 5 . 789–94 . 1998 . 9535005 . 10.1038/sj.bjp.0701665 . 1565225 .
• Tai CJ, Kang SK, Cheng KW, etal . Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells. . J. Clin. Endocrinol. Metab. . 85 . 4 . 1591–7 . 2000 . 10.1210/jcem.85.4.6558 . 10770202 . free .
• Erb L, Liu J, Ockerhausen J, etal . An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. . J. Cell Biol. . 153 . 3 . 491–501 . 2001 . 11331301 . 10.1083/jcb.153.3.491 . 2190579 .
• Moore DJ, Chambers JK, Wahlin JP, etal . Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. . Biochim. Biophys. Acta . 1521 . 1–3 . 107–19 . 2001 . 11690642 . 10.1016/S0167-4781(01)00291-3.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR . Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. . J. Invest. Dermatol. . 120 . 3 . 440–7 . 2003 . 12603858 . 10.1046/j.1523-1747.2003.12050.x . free .
• Schafer R, Sedehizade F, Welte T, Reiser G . ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. . Am. J. Physiol. Lung Cell Mol. Physiol. . 285 . 2 . L376–85 . 2003 . 12691958 . 10.1152/ajplung.00447.2002 . 108677 .
• Seye CI, Yu N, Jain R, etal . The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells. . J. Biol. Chem. . 278 . 27 . 24960–5 . 2003 . 12714597 . 10.1074/jbc.M301439200 . free.
• Greig AV, Linge C, Terenghi G, etal . Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. . J. Invest. Dermatol. . 120 . 6 . 1007–15 . 2003 . 12787128 . 10.1046/j.1523-1747.2003.12261.x .
• Greig AV, Linge C, Healy V, etal . Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. . J. Invest. Dermatol. . 121 . 2 . 315–27 . 2003 . 12880424 . 10.1046/j.1523-1747.2003.12379.x . free .
• Meshki J, Tuluc F, Bredetean O, etal . Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor. . Am. J. Physiol., Cell Physiol. . 286 . 2 . C264–71 . 2004 . 14613890 . 10.1152/ajpcell.00287.2003 . 21388137 .
• Haserück N, Erl W, Pandey D, etal . The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. . Blood . 103 . 7 . 2585–92 . 2004 . 14645014 . 10.1182/blood-2003-04-1127 . free .

External links

• Web site: P2Y Receptors: P2Y₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303202234/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2394 . dead .

Notes and References

1. Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT . Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy . Proc Natl Acad Sci USA . 91 . 8 . 3275–9 . May 1994 . 8159738 . 43559 . 10.1073/pnas.91.8.3275 . 1994PNAS...91.3275P . free .
2. Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ . Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family . Genomics . 44 . 1 . 127–30 . Nov 1997 . 9286708 . 10.1006/geno.1997.4841 .
3. Web site: Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2.