P2RY1 explained

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.^[1]

Function

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.^[2]

See also

• P2Y receptor

Further reading

• Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM . Cloning and tissue distribution of the human P2Y1 receptor . Biochemical and Biophysical Research Communications . 221 . 3 . 588–93 . April 1996 . 8630005 . 10.1006/bbrc.1996.0640 .
• Léon C, Vial C, Cazenave JP, Gachet C . Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor . Gene . 171 . 2 . 295–7 . June 1996 . 8666290 . 10.1016/0378-1119(96)00027-3 .
• Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C . The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells . FEBS Letters . 403 . 1 . 26–30 . February 1997 . 9038354 . 10.1016/S0014-5793(97)00022-7 . 10518131 .
• Ayyanathan K, Naylor SL, Kunapuli SP . Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1) . Somatic Cell and Molecular Genetics . 22 . 5 . 419–24 . September 1996 . 9039850 . 10.1007/BF02369897 . 28971344 .
• Maier R, Glatz A, Mosbacher J, Bilbe G . Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues . Biochemical and Biophysical Research Communications . 237 . 2 . 297–302 . August 1997 . 9268704 . 10.1006/bbrc.1997.7135 .
• Jin J, Daniel JL, Kunapuli SP . Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets . The Journal of Biological Chemistry . 273 . 4 . 2030–4 . January 1998 . 9442040 . 10.1074/jbc.273.4.2030 . free .
• Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ . A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins . Proceedings of the National Academy of Sciences of the United States of America . 95 . 15 . 8496–501 . July 1998 . 9671706 . 21104 . 10.1073/pnas.95.15.8496 . 1998PNAS...95.8496H . free .
• Sabala P, Czajkowski R, Przybyłek K, Kalita K, Kaczmarek L, Barańska J . Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells . British Journal of Pharmacology . 132 . 2 . 393–402 . January 2001 . 11159687 . 1572584 . 10.1038/sj.bjp.0703843 .
• Yoshioka K, Saitoh O, Nakata H . Heteromeric association creates a P2Y-like adenosine receptor . Proceedings of the National Academy of Sciences of the United States of America . 98 . 13 . 7617–22 . June 2001 . 11390975 . 34717 . 10.1073/pnas.121587098 . free . 2001PNAS...98.7617Y .
• James G, Butt AM . Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve . Neuroscience Letters . 312 . 1 . 33–6 . October 2001 . 11578839 . 10.1016/S0304-3940(01)02189-9 . 30936205 .
• Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR . Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1521 . 1–3 . 107–19 . October 2001 . 11690642 . 10.1016/S0167-4781(01)00291-3 .
• Czajkowski R, Lei L, Sabała P, Barańska J . ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12) . FEBS Letters . 513 . 2–3 . 179–83 . February 2002 . 11904146 . 10.1016/S0014-5793(02)02255-X . 43212335 .
• Aktas B, Hönig-Liedl P, Walter U, Geiger J . Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase . Biochemical Pharmacology . 64 . 3 . 433–9 . August 2002 . 12147294 . 10.1016/S0006-2952(02)01113-9 .
• Nurden P, Poujol C, Winckler J, Combrié R, Pousseau N, Conley PB, Levy-Toledano S, Habib A, Nurden AT . Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system . Blood . 101 . 4 . 1400–8 . February 2003 . 12393588 . 10.1182/blood-2002-02-0642 . 30407515 . free .
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR . Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors . The Journal of Investigative Dermatology . 120 . 3 . 440–7 . March 2003 . 12603858 . 10.1046/j.1523-1747.2003.12050.x . free .
• Jagroop IA, Burnstock G, Mikhailidis DP . Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets . Platelets . 14 . 1 . 15–20 . February 2003 . 12623443 . 10.1080/0953710021000062914 . 13637415 .
• Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G . Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes . The Journal of Investigative Dermatology . 120 . 6 . 1007–15 . June 2003 . 12787128 . 10.1046/j.1523-1747.2003.12261.x .
• Wang L, Ostberg O, Wihlborg AK, Brogren H, Jern S, Erlinge D . Quantification of ADP and ATP receptor expression in human platelets . Journal of Thrombosis and Haemostasis . 1 . 2 . 330–6 . February 2003 . 12871508 . 10.1046/j.1538-7836.2003.00070.x . 19101147 .

External links

• Web site: P2Y Receptors: P2Y₁ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303174316/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2392 . dead .

Notes and References

1. Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP . Cloning and chromosomal localization of the human P2Y1 purinoceptor . Biochemical and Biophysical Research Communications . 218 . 3 . 783–8 . January 1996 . 8579591 . 10.1006/bbrc.1996.0139 .
2. Web site: Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1.