P2RY8 explained

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.^{[1] [2]}

Function

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.^[2]

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.^[3]

See also

• P2Y receptor

Further reading

• Cantagrel V, Lossi AM, Boulanger S, Depetris D, Mattei MG, Gecz J, Schwartz CE, Van Maldergem L, Villard L . Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males . Journal of Medical Genetics . 41 . 10 . 736–42 . Oct 2004 . 15466006 . 1735597 . 10.1136/jmg.2004.021626 .
• Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K, Mano H . Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening . Leukemia & Lymphoma . 48 . 5 . 978–86 . May 2007 . 17487742 . 10.1080/10428190701225882 . 678068 .
• Storlazzi CT, Albano F, Lo Cunsolo C, Doglioni C, Guastadisegni MC, Impera L, Lonoce A, Funes S, Macrì E, Iuzzolino P, Panagopoulos I, Specchia G, Rocchi M . Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma . Leukemia . 21 . 10 . 2221–5 . Oct 2007 . 17554380 . 10.1038/sj.leu.2404784 . free .

Notes and References

1. Adrian K, Bernhard MK, Breitinger HG, Ogilvie A . Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1492 . 1 . 127–38 . Jun 2000 . 11004484 . 10.1016/S0167-4781(00)00094-4 .
2. Web site: Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8.
3. Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR . Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing . Proceedings of the National Academy of Sciences of the United States of America . 109 . 10 . 3879–84 . Mar 2012 . 22343534 . 3309757 . 10.1073/pnas.1121343109 . 2012PNAS..109.3879L . free .