P2RY6 explained

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.^{[1] [2]}

Function

The product of this gene, P2Y₆, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.^[2]

See also

• P2Y receptor

References

Further reading

• Maier R, Glatz A, Mosbacher J, Bilbe G . Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues . Biochemical and Biophysical Research Communications . 237 . 2 . 297–302 . Aug 1997 . 9268704 . 10.1006/bbrc.1997.7135 .
• Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ . Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family . Genomics . 44 . 1 . 127–30 . Aug 1997 . 9286708 . 10.1006/geno.1997.4841 .
• Pidlaoan LV, Jin J, Sandhu AK, Athwal RS, Kunapuli SP . Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1 . Somatic Cell and Molecular Genetics . 23 . 4 . 291–6 . Jul 1997 . 9542531 . 10.1007/BF02674420 . 24535480 .
• Brinson AE, Harden TK . Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor . The Journal of Biological Chemistry . 276 . 15 . 11939–48 . Apr 2001 . 11114308 . 10.1074/jbc.M009909200 . free .
• Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR . Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1521 . 1–3 . 107–19 . Oct 2001 . 11690642 . 10.1016/S0167-4781(01)00291-3 .
• Hou M, Harden TK, Kuhn CM, Baldetorp B, Lazarowski E, Pendergast W, Möller S, Edvinsson L, Erlinge D, Schmoldt A, Benthe HF, Haberland G, Klimpel GR, Day KD, Lucas DO, Kalyanaraman VS, Mahadevan S, Kumar SA, Wachter RF, Briggs GP, Pedersen CE, Nozaki M, Bose KS, Sarma RH, Granström G, Linde A . UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors . Am J Physiol Heart Circ Physiol . 282 . 2 . H784–92 . Feb 2002 . 11788430 . 10.1152/ajpheart.00997.2000 . 19082766 .
• Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG . Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation . The Journal of Biological Chemistry . 278 . 7 . 4590–6 . Feb 2003 . 12464620 . 10.1074/jbc.M207868200 . free .
• Kim SG, Soltysiak KA, Gao ZG, Chang TS, Chung E, Jacobson KA . Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors . Biochemical Pharmacology . 65 . 6 . 923–31 . Mar 2003 . 12623123 . 3402349 . 10.1016/S0006-2952(02)01614-3 .
• Schafer R, Sedehizade F, Welte T, Reiser G . ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells . American Journal of Physiology. Lung Cellular and Molecular Physiology . 285 . 2 . L376–85 . Aug 2003 . 12691958 . 10.1152/ajplung.00447.2002 . 108677 .
• Lee H, Choi BH, Suh BC, Lee SK, Kim KT . Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells . Journal of Neurochemistry . 85 . 4 . 1043–53 . May 2003 . 12716436 . 10.1046/j.1471-4159.2003.01761.x . 24830829 . free .
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proceedings of the National Academy of Sciences of the United States of America . 101 . 44 . 15724–9 . Nov 2004 . 15498874 . 524842 . 10.1073/pnas.0404089101 . 2004PNAS..10115724W . free .
• Cox MA, Gomes B, Palmer K, Du K, Wiekowski M, Wilburn B, Petro M, Chou CC, Desquitado C, Schwarz M, Lunn C, Lundell D, Narula SK, Zavodny PJ, Jenh CH . The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP . Biochemical and Biophysical Research Communications . 330 . 2 . 467–73 . May 2005 . 15796906 . 10.1016/j.bbrc.2005.03.004 .
• Khine AA, Del Sorbo L, Vaschetto R, Voglis S, Tullis E, Slutsky AS, Downey GP, Zhang H . Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway . Blood . 107 . 7 . 2936–42 . Apr 2006 . 16322472 . 10.1182/blood-2005-06-2314 . 1807/17906 . free . free .
• Wihlborg AK, Balogh J, Wang L, Borna C, Dou Y, Joshi BV, Lazarowski E, Jacobson KA, Arner A, Erlinge D . Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction . Circulation Research . 98 . 7 . 970–6 . Apr 2006 . 16543499 . 3492942 . 10.1161/01.RES.0000217402.73402.cd .
• Dulong S, Bernard K, Ehrenfeld J . Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells . Cellular Physiology and Biochemistry . 20 . 5 . 483–94 . 2007 . 17762175 . 10.1159/000107532 . free .

External links

• Web site: P2Y Receptors: P2Y₆ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2015-02-17 . https://web.archive.org/web/20150217120540/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2398 . dead .

Notes and References

1. Communi D, Parmentier M, Boeynaems JM . Cloning, functional expression and tissue distribution of the human P2Y6 receptor . Biochemical and Biophysical Research Communications . 222 . 2 . 303–8 . May 1996 . 8670200 . 10.1006/bbrc.1996.0739 .
2. Web site: Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6.