| Pánuco | |
| Settlement Type: | City & municipal seat |
| Mapsize: | 300px |
| Pushpin Map: | Mexico Zacatecas#Mexico |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Zacatecas |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Pánuco |
| Leader Title: | Municipal President |
| Established Title: | Founded |
| Established Date: | 1 November 1548 |
| Established Title2: | City status |
| Population As Of: | 2020 |
| Population Total: | 1,177 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 22.5233°N -102.3225°W |
| Elevation M: | 2292 |
| Postal Code Type: | Postal code |
| Area Code: | 846 |
| Blank Name: | Demonym |
| Website: | www.panuco.gob.mx |
Pánuco (pronounced as /es/) is a locality in the Mexican state of Zacatecas. It serves as the municipal seat of the eponymous Pánuco Municipality.
Pánuco was founded on 1 November 1548 by explorers Diego de Ibarra, Francisco de Ibarra, and Cristóbal de Oñate.[1] It became the seat of the eponymous municipality upon its foundation in 1824.[2]
In the 2020 Mexican Census, Pánuco recorded a population of 1,177 inhabitants living in 434 households.[3]